Evidence map›Paper›PMID 40021014›Full record

ArticleVirus research2025

Exploration of mycovirus composition in a hypovirulent strain of Sclerotinia sclerotiorum potentially uncovers mycovirus cross-taxa transmission.

Lixia Gao, Weimeng Li, Jichun Jia, Jiasen Cheng, Yanping Fu, Xueqiong Xiao, Qing Cai, Yang Lin, Tao Chen, Bo Li and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virus research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Lixia GaoNational Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China; Hubei Key Laboratory of Plant Pathology, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan, China; Hubei Hongshan Laboratory, Wuhan, China.
Weimeng LiNational Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China; Hubei Key Laboratory of Plant Pathology, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan, China; Hubei Hongshan Laboratory, Wuhan, China.
Jichun JiaCollege of Plant Protection, Laboratory of Integrated Pest Management in Agriculture, Shanxi Agricultural University, Jinzhong, Shanxi, China.
Jiasen ChengNational Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China; Hubei Key Laboratory of Plant Pathology, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan, China.
Yanping FuHubei Key Laboratory of Plant Pathology, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan, China.
Xueqiong XiaoNational Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China; Hubei Key Laboratory of Plant Pathology, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan, China.
Qing CaiNational Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China.
Yang LinHubei Key Laboratory of Plant Pathology, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan, China.
Tao ChenNational Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China; Hubei Key Laboratory of Plant Pathology, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan, China; Hubei Hongshan Laboratory, Wuhan, China.
Bo LiNational Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China; Hubei Key Laboratory of Plant Pathology, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan, China; Hubei Hongshan Laboratory, Wuhan, China.
Xiao YuNational Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China; Hubei Key Laboratory of Plant Pathology, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan, China; Hubei Hongshan Laboratory, Wuhan, China.
Tom HsiangEnvironmental Sciences, University of Guelph, Guelph, Ontario, Canada.
Daohong JiangNational Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China; Hubei Key Laboratory of Plant Pathology, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan, China; Hubei Hongshan Laboratory, Wuhan, China.
Jiatao XieNational Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China; Hubei Key Laboratory of Plant Pathology, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan, China; Hubei Hongshan Laboratory, Wuhan, China. Electronic address: jiataoxie@mail.hzau.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sclerotinia sclerotiorum is a worldwide plant pathogenic fungus. Identifying novel mycoviruses in this fungus can aid in developing fungal disease control strategies and enhance our understanding of viral evolution. Here, we analyzed mycovirus composition in S. sclerotiorum strain XZ69, and identified six ssRNA mycoviruses, including five known mycoviruses and one unassigned mycovirus. The newly identified mycovirus, tentatively named Sclerotinia sclerotiorum narna-like virus 1 (SsNLV1/XZ69), possesses a full-length genome of 3534 nucleotides, containing a single ORF that encodes an RNA-dependent RNA polymerase (RdRp) of 1090 amino acids. The RdRp encoded by SsNLV1/XZ69 shares 60.4 % identity with that encoded by Monilinia narnavirus H. SsNLV1/XZ69 phylogenetically clusters with unclassified narna-like viruses potentially infecting fungi, plants, and animals, and they form an independent branch that is distant from established families, therefore supporting the establishment of a new family to accommodate these viruses. Sclerotinia sclerotiorum fusarivirus 3 (SsFV3/XZ69) share 97 % amino acid identities with preciously reported Botrytis cinerea fusarivirus 8 (BcFV8). This last mycovirus originated from Botrytis cinerea, and hence this reveals that cross-genus transmission of SsFV3 or BcFV8 between B. cinerea and S. sclerotiorum may have potentially occurred. Mycovirus elimination, horizontal transmission, and RNA transfection experiments revealed that Sclerotinia sclerotiorum negative-stranded RNA virus 1 (SsNSRV1/XZ69), SsNSRV2/XZ69, and SsFV3/XZ69 may be associated with hypovirulence in S. sclerotiorum, and strain XZ69 exhibits potential disease biocontrol on rapeseed seedlings. Our study expands our understanding of viral evolution, and may provide new potential biocontrol agents for S. sclerotiorum.

Indexed as

AscomycotaFungal VirusesRNA VirusesGenome, ViralOpen Reading FramesPhylogenyPlant DiseasesRNA-Dependent RNA PolymeraseRNA, ViralViral ProteinsRNA-Dependent RNA PolymeraseRNA, ViralViral ProteinsCo-infectionsHypovirulenceMycovirusesSclerotinia sclerotiorum

Identifiers

PMID40021014
PMCPMC11925586

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.