Evidence map›Paper›PMID 40020888›Full record

ArticleCellular signalling2025

Regulatory differences between atypical and typical MAP kinases in Dictyostelium discoideum.

Ramee G Aranda, Saher Fatima, Md Ikram Rafid, Imani McGill, Jeffrey A Hadwiger

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular signalling, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ramee G ArandaDepartment of Microbiology and Molecular Genetics, Oklahoma State University, Stillwater, OK 74078-3020, United States of America.
Saher FatimaDepartment of Microbiology and Molecular Genetics, Oklahoma State University, Stillwater, OK 74078-3020, United States of America.
Md Ikram RafidDepartment of Microbiology and Molecular Genetics, Oklahoma State University, Stillwater, OK 74078-3020, United States of America.
Imani McGillDepartment of Microbiology and Molecular Genetics, Oklahoma State University, Stillwater, OK 74078-3020, United States of America.
Jeffrey A HadwigerDepartment of Microbiology and Molecular Genetics, Oklahoma State University, Stillwater, OK 74078-3020, United States of America. Electronic address: jeff.hadwiger@okstate.edu.

Funding

G-RISE at Oklahoma State UniversityT32GM140953 · NIGMS · OKLAHOMA STATE UNIVERSITY STILLWATER · PI LOVERN, MATTHEW, LOVERN, PAMELA C · 2021 to 2024
$1.5M
Atypical MAP Kinase Signal TransductionR15GM131269 · NIGMS · OKLAHOMA STATE UNIVERSITY STILLWATER · PI HADWIGER, JEFFREY A · 2019 to 2022
$914k
NIGMS NIH HHS R15 GM131269NIGMS NIH HHS T32 GM140953
6 · The paper itself

Abstract

Within the large family of mitogen activated protein kinases (MAPKs), one outlier group referred to as atypical MAPKs is not regulated by conventional upstream MAPK kinases (MAP2Ks). This includes the Dictyostelium discoideum atypical MAPK Erk2, a protein kinase essential for chemotactic movement and development. The regulation and functional specificity of Erk2 was investigated through phenotypic analysis of chimeric and mutant MAPKs. Chimeric MAPKs containing regions of Erk2 were created using complementary regions of the more typical MAPK Erk1, that provides very different functions in this amoeba. The chimeric MAPKs were not phosphorylated at levels observed for wild-type MAPKs and none rescued wild-type MAPK function to erk1

Indexed as

DictyosteliumMitogen-Activated Protein Kinase 1Mitogen-Activated Protein KinasesProtozoan ProteinsAmino Acid MotifsAmino Acid SequenceMitogen-Activated Protein Kinase 3PhosphorylationMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3Mitogen-Activated Protein KinasesProtozoan ProteinsChemotaxisDevelopmentMAP kinaseSignal transduction

Identifiers

PMID40020888
PMCPMC11908898

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.