ArticleBiological psychiatry2025
Emergence and Dynamics of Delusions and Hallucinations Across Stages in Early Psychosis.
Article in Biological psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Further Evidence Is Needed to Support the Perceptual Theory of Schizophrenia.Biological psychiatry global open science · 2026Article
- A circuit dissection of perception-action decoupling in S-ketamine-induced hallucination-like states.Molecular psychiatry · 2026Article
- Dynamic, differentiated clinical trajectories and prediction in clinical high risk for psychosis.Molecular psychiatry · 2026Article
- It Is What It Isn't: Introducing a Constraint-Based Approach to Structure Learning.Entropy (Basel, Switzerland) · 2026Article
- Threading the Needle: Practical Considerations for Merging Theory-Driven Computational Psychiatry With Data-Driven Analytics to Enhance Precision Health at Scale.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Review
- Rubber voice illusion exposed neural correlates of voice perception and vocal adaptation across the continuum of psychosis.Scientific reports · 2026Article
- Compensatory hallucinogenesis across three neuropsychiatric disorders: a Bayesian account.Brain communications · 2026Review
- Using machine learning to predict persecutory beliefs based on aetiological models of delusions identified in a systematic literature search.Communications psychology · 2025Article
- The role of affective states in computational psychiatry.The international journal of neuropsychopharmacology · 2025Review
- Subtyping first-episode psychosis based on longitudinal symptom trajectories using machine learning.Npj mental health research · 2025Article
- A Computational Account of the Development and Evolution of Psychotic Symptoms.Biological psychiatry · 2025Review
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Authors and funding
24 authors.
Funding
Abstract
backgroundHallucinations and delusions are often grouped together as positive symptoms of psychosis. However, recent evidence suggests that they may be driven by distinct computational and neural mechanisms. Examining the time course of their emergence may provide insights into the relationship between these underlying mechanisms.
methodsParticipants from the second (N = 719) and third (N = 699) iterations of the North American Prodrome Longitudinal Study (NAPLS 2 and 3) were assessed for timing of clinical high risk for psychosis (CHR-P)-level delusion and hallucination onset. Pre-onset symptom patterns in patients with first-episode psychosis from the Prevention and Early Intervention Program for Psychosis (PEPP-Montréal) (N = 694) were also assessed. Symptom onset was determined at the baseline assessment, and the evolution of symptom patterns was examined over 24 months.
resultsIn all 3 samples, participants were more likely to report the onset of attenuated/subthreshold delusions prior to attenuated/subthreshold hallucinations (odds ratios [ORs]: NAPLS 2 = 4.09; NAPLS 3 = 4.14; PEPP, z = 7.01, p < .001) and to present with only attenuated/subthreshold delusions compared with only attenuated/subthreshold hallucinations (ORs: NAPLS 2 = 5.6; NAPLS 3 = 11.11; PEPP = 42.75). The reemergence of attenuated/subthreshold delusions after remission was also more common than reemergence of attenuated/subthreshold hallucinations (ps < .05), which more often resolved first (ps < .001). In both CHR-P samples, ratings of delusional ideation decreased with the onset of attenuated hallucinations (p = .007).
conclusionsAttenuated/subthreshold delusions tend to emerge before attenuated/subthreshold hallucinations and may play a role in their development. Future work should examine the relationship between the mechanisms that drive these symptoms and its utility for diagnosis and treatment.
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