Observational studyJornal de pediatria
Pulmonary artery systolic pressure associated with inflammatory factors among pediatric congenital heart disease with pulmonary arterial hypertension after cardiopulmonary bypass.
Observational study in Jornal de pediatria. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study aimed to evaluate the perioperative inflammatory cytokines in pediatric patients with pulmonary arterial hypertension secondary to congenital heart disease and also sought to investigate the correlation between preoperative echocardiographic pulmonary artery systolic pressure and inflammatory factors after cardiopulmonary bypass in these patients.
methodsA retrospective observational study was conducted involving 59 children under 2 years old. Echocardiography was used to measure tricuspid annular peak systolic velocity. The levels of perioperative inflammatory cytokines in the plasma, including IL-6, IL-8, IL-10, IL-1β, and TNF-α, were measured. Additionally, postoperative ventilation time, length of intensive care unit stay, and ward stay were recorded.
resultsPatients with pulmonary hypertension experience longer postoperative ventilation time, intensive care unit stay, and ward stay. Although no significant differences were observed in the cardiopulmonary bypass and aortic cross-clamping, there was a more pronounced increase in postoperative inflammatory cytokines, including IL-6, IL-8, and IL-10, in these patients following cardiopulmonary bypass (p < 0.05). Preoperative echocardiographic pulmonary artery systolic pressure was found to be associated with the levels of IL-6 and IL-10 after surgery in pulmonary hypertension patients. A pulmonary artery systolic pressure greater than 52 mmHg was able to predict a postoperative ventilation time exceeding 21 h.
conclusionHigher levels of inflammatory cytokines were observed in pediatric patients with pulmonary hypertension secondary to congenital heart disease following cardiopulmonary bypass. Additionally, preoperative elevation in echocardiographic pulmonary artery systolic pressure was associated with increased postoperative inflammatory markers, suggesting a potential correlation with adverse early postoperative clinical outcomes.
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