Evidence map›Paper›PMID 40020642›Full record

Trial reportDrug and alcohol dependence2025

Adaptive interventions for alcohol misuse and violent behaviors among adolescents and emerging adults in the emergency department: Outcomes from a sequential multiple assignment randomized controlled trial.

Maureen A Walton, Laura Seewald, Patrick M Carter, Quyen Ngo, Frederic C Blow, Carrie Bourque, Claire Pearson, Katherine A Battisti, Larry An, Mari Wank and 2 more

Abstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Drug and alcohol dependence, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Maureen A WaltonAddiction Center, Department of Psychiatry, University of Michigan, Ann Arbor, MI 48109, USA; Injury Prevention Center, University of Michigan, Ann Arbor, MI 48109, USA; Institute on Firearm Injury Prevention, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: waltonma@med.umich.edu.
Laura SeewaldInjury Prevention Center, University of Michigan, Ann Arbor, MI 48109, USA; Institute on Firearm Injury Prevention, University of Michigan, Ann Arbor, MI 48109, USA; Department of Emergency Medicine, University of Michigan, Ann Arbor, MI 48109-2800, USA.
Patrick M CarterInjury Prevention Center, University of Michigan, Ann Arbor, MI 48109, USA; Institute on Firearm Injury Prevention, University of Michigan, Ann Arbor, MI 48109, USA; Department of Emergency Medicine, University of Michigan, Ann Arbor, MI 48109-2800, USA.
Quyen NgoHazelden Betty Ford Foundation, Center City, MN 55012, USA.
Frederic C BlowAddiction Center, Department of Psychiatry, University of Michigan, Ann Arbor, MI 48109, USA.
Carrie BourqueAddiction Center, Department of Psychiatry, University of Michigan, Ann Arbor, MI 48109, USA.
Claire PearsonDepartment of Emergency Medicine, Wayne State University, Detroit, MI 48201, USA.
Katherine A BattistiDepartment of Emergency Medicine, Central Michigan University, Saginaw, MI 48109, USA.
Larry AnDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
Mari WankDepartment of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA.
Yanruyu ZhuDepartment of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA.
Kelley M KidwellDepartment of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA.

Funding

XenograftP30CA046592 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Eric R. Fearon · 1988 to 2026
$178.2M
Adaptive Interventions to Reduce Risky Drinking and Violent Behaviors among AdolescentsR01AA024755 · NIAAA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WALTON, MAUREEN A · 2016 to 2020
$2.9M
Firearm Safety Among Children and Teens (FACTS): Multi-Disciplinary Research Training ProgramT32HD108054 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Patrick M. Carter, Marc A Zimmerman · 2022 to 2026
$1.7M
NCI NIH HHS P30 CA046592NIAAA NIH HHS R01 AA024755NICHD NIH HHS T32 HD108054
6 · The paper itself

Abstract

introductionHarnessing technology for delivery of behavioral health interventions to reduce alcohol use and aggression may reduce morbidity among youth. This paper describes the outcomes from a sequential, multiple assignment, randomized trial (SMART) testing interventions for youth (ages 14-20) in the emergency department (ED).

methodsYouth (n = 400) in the ED screening positive for binge drinking and aggression received the SafERteens brief intervention (BI) and were randomly assigned to boosters: Text Messages (TM) or Health Coach (HC) (1st stage; weeks 1-4). Participants completed 8 weekly surveys, with outcomes assessed at 4- and 8-months. After the 1st stage, response/non-response was determined (e.g., binge drinking or aggression). Responders were re-randomized to continued or minimized condition; non-responders were re-randomized to continued or intensified condition (2nd stage; weeks 5-8). Analyses examined outcomes from the initial randomization; and comparisons between responders and non-responders on primary (alcohol consumption, aggression), secondary (alcohol consequences, violence consequences) and exploratory (alcohol misuse, victimization, drug use, drug consequences) outcomes.

resultsThere were no significant differences in outcomes between 1st stage boosters or 2nd stage boosters for non-responder or responder groups. However, significant changes over time were observed across all participants, with the odds of abstaining from alcohol increased at 4 (OR 3.97, 95 % CI 2.46-6.41) and 8-months (OR 4.36, 95 % CI 2.11-9.02), while the odds of aggression (OR 0.39, 95 % CI 0.16-0.94) decreased at 8-months; significant decreases were also observed for other outcomes.

conclusionsFindings support the promise of digital health interventions for youth with binge drinking and aggression.

Indexed as

AlcoholismEmergency Service, HospitalViolenceAdolescentAggressionBinge DrinkingFemaleHumansMaleText MessagingTreatment OutcomeYoung AdultAggressionAlcohol misuseSMARTViolent behaviorsYouth

Identifiers

PMID40020642
PMCPMC11951956

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.