Evidence map›Paper›PMID 40020285›Full record

ArticleClinics (Sao Paulo, Brazil)2025

The phenotype of monocyte subtypes and expression of chemokine receptors in the Chronic Venous Insufficiency.

Danielle Borges Germano, Larissa Namie Chiba, Ana Paula Augusto da Cruz Ballerini, Jônatas Bussador do Amaral, Marina Tiemi Shio, Jhefferson Miranda Alves, Daniela Alves de Abreu, Luiz Henrique da Silva Nali, Francisco Antonio Helfenstein Fonseca, Maria Cristina Izar and 2 more

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Article in Clinics (Sao Paulo, Brazil), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

Who cites it

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Danielle Borges GermanoPost-Graduation Program in Health Sciences, Universidade Santo Amaro, São Paulo, SP, Brazil.
Larissa Namie ChibaPost-Graduation Program in Health Sciences, Universidade Santo Amaro, São Paulo, SP, Brazil; Urology Program, Faculdade de Medicine, Universidade de São Paulo, São Paulo, SP, Brazil.
Ana Paula Augusto da Cruz BalleriniPost-Graduation Program in Health Sciences, Universidade Santo Amaro, São Paulo, SP, Brazil.
Jônatas Bussador do AmaralENT Research Lab., Department of Otorhinolaryngology Head and Neck Surgery, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
Marina Tiemi ShioPost-Graduation Program in Health Sciences, Universidade Santo Amaro, São Paulo, SP, Brazil.
Jhefferson Miranda AlvesPost-Graduation Program in Health Sciences, Universidade Santo Amaro, São Paulo, SP, Brazil.
Daniela Alves de AbreuPost-Graduation Program in Health Sciences, Universidade Santo Amaro, São Paulo, SP, Brazil.
Luiz Henrique da Silva NaliPost-Graduation Program in Health Sciences, Universidade Santo Amaro, São Paulo, SP, Brazil.
Francisco Antonio Helfenstein FonsecaUniversidade Federal de São Paulo, São Paulo, SP, Brazil.
Maria Cristina IzarUniversidade Federal de São Paulo, São Paulo, SP, Brazil.
André Luis Lacerda BachiPost-Graduation Program in Health Sciences, Universidade Santo Amaro, São Paulo, SP, Brazil.
Carolina Nunes FrançaPost-Graduation Program in Health Sciences, Universidade Santo Amaro, São Paulo, SP, Brazil. Electronic address: carolufscar24@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe aim of this study was to evaluate monocyte subtypes and the chemokine receptors, comparing individuals with and without Chronic Venous Insufficiency (CVI).

methodThe authors included patients undergoing surgery for varicose veins of the lower limbs (Classification of Venous Disorders - CEAP: C1‒C3).

resultsThere were increased levels of classical and non-classical monocytes in the case group and a reduction in intermediate monocytes. Besides, there was higher expression of CCR5 in the non-classical monocytes and lower expression of CX3CR1 in the classical monocytes in the case group.

conclusionsThe inflammatory process present in patients with CVI can modulate the monocyte phenotype and the expression of the chemokine receptors at the protein level.

Indexed as

MonocytesReceptors, ChemokineVenous InsufficiencyAdultAgedCase-Control StudiesChronic DiseaseFemaleHumansMaleMiddle AgedPhenotypeVaricose VeinsReceptors, ChemokineChemokine receptorsChronic venous insufficiencyMonocyte subtypes

Identifiers

PMID40020285
PMCPMC11910344

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.