ArticleMedicine2025
The causal relationship between thyroid dysfunction and carpal tunnel syndrome: A Mendelian randomization study.
Article in Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
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Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Serum Biomarkers for Traumatic Peripheral Nerve Injury: A Systematic Review.Muscle & nerve · 2025Pooled it
- Clinical and demographic factors associated with coexisting carpal tunnel syndrome and trigger finger in Kazakhstan.Orthopedic reviews · 2026Article
- Correlation of body composition and anthropometric indices with electrodiagnostic and ultrasonographic findings in patients with carpal tunnel syndrome.BMC musculoskeletal disorders · 2025Article
- Effect of Hypothyroidism on the Risk of Carpal Tunnel Syndrome and Electrodiagnostic Parameters.Neurology international · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mendelian randomization was used to investigate the causal relationship between thyroid dysfunction (including hypothyroidism and hyperthyroidism) and carpal tunnel syndrome. Genetic loci independently associated with hypothyroidism and hyperthyroidism were selected as instrumental variables from pooled data from genome-wide association studies. Inverse variance weighting (IVW) was used to analyze the causal effect, supplemented by weighted median and MR-Egger. Heterogeneity test, pleiotropy testing and leave-one-out analysis were used to analyze the sensitivity test to explore the robustness of the results. Both hypothyroidism and hyperthyroidism increase the risk of carpal tunnel syndrome (hypothyroidism: IVW, OR = 1.04, 95% CI = 1.01-1.08, P = .017; hyperthyroidism: IVW, OR = 1.08, 95% CI = 1.05-1.12, P = 9.218E-06, no pleiotropy was found in both tests. Patients with thyroid dysfunction have an increased risk of carpal tunnel syndrome.
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Registered trials
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