Evidence map›Paper›PMID 40020063›Full record

ArticleScience advances2025

Increased levels of lagging strand polymerase α in an adult stem cell lineage affect replication-coupled histone incorporation.

Brendon E M Davis, Jonathan Snedeker, Rajesh Ranjan, Matthew Wooten, Savannah Sáde Barton, Joshua Blundon, Xin Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Reevaluation of whether histones are asymmetrically segregated during asymmetric divisions of stem cells inProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Brendon E M DavisDepartment of Biology, The Johns Hopkins University, Baltimore, MD 21218, USA.ORCID 0000-0002-7672-5038
Jonathan SnedekerDepartment of Biology, The Johns Hopkins University, Baltimore, MD 21218, USA.
Rajesh RanjanDepartment of Biology, The Johns Hopkins University, Baltimore, MD 21218, USA.ORCID 0000-0003-1368-6067
Matthew WootenDepartment of Biology, The Johns Hopkins University, Baltimore, MD 21218, USA.ORCID 0000-0001-8629-9899
Savannah Sáde BartonDepartment of Biology, The Johns Hopkins University, Baltimore, MD 21218, USA.
Joshua BlundonDepartment of Biology, The Johns Hopkins University, Baltimore, MD 21218, USA.ORCID 0009-0009-8412-6818
Xin ChenDepartment of Biology, The Johns Hopkins University, Baltimore, MD 21218, USA.ORCID 0000-0002-6990-0926

Funding

CELLULAR AND MOLECULAR BIOLOGYT32GM007231 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI VAN DOREN, MARK B · 1985 to 2020
$18.4M
Study epigenetic inheritance during development, homeostasis and regenerationR35GM127075 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI Xin Chen · 2018 to 2026
$3.2M
Epigenetic Regulation of Germ Cell Differentiation from a Stem Cell LineageR01HD102474 · NICHD · JOHNS HOPKINS UNIVERSITY · PI CHEN, XIN · 2020 to 2024
$1.7M
Mechanism and Regulation of Replication-Coupled Asymmetric Histone Incorporation in Drosophila Male Germline Stem CellsF31HD116510 · NICHD · JOHNS HOPKINS UNIVERSITY · PI Brendon Eugene Michael Davis · 2024 to 2026
$149k
Investigating the mechanisms and generality of asymmetric histone inheritance in multiple stem cell systemsF31GM115149 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI WOOTEN, MATTHEW · 2016 to 2017
$88k
Investigating the molecular mechanisms of asymmetric histone incorporation during DNA replicationF31HD104526 · NICHD · JOHNS HOPKINS UNIVERSITY · PI SNEDEKER, JONATHAN · 2021 to 2022
$66k
NICHD NIH HHS F31 HD104526NICHD NIH HHS F31 HD116510NICHD NIH HHS R01 HD102474NIGMS NIH HHS F31 GM115149NIGMS NIH HHS R35 GM127075NIGMS NIH HHS T32 GM007231
6 · The paper itself

Abstract

Stem cells display asymmetric histone inheritance, while nonstem progenitor cells exhibit symmetric patterns in the

Indexed as

Adult Stem CellsCell LineageDNA Polymerase IDNA ReplicationDrosophila ProteinsHistonesAnimalsChromatinDrosophila melanogasterMaleChromatinDNA Polymerase IDrosophila ProteinsHistones

Identifiers

PMID40020063
PMCPMC11870066

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.