Evidence map›Paper›PMID 40020054›Full record

ArticleScience advances2025

Optogenetic quantification of cardiac excitability and electrical coupling in intact hearts to explain cardiac arrhythmia initiation.

Judith S Langen, Patrick M Boyle, Daniela Malan, Philipp Sasse

Abstract read
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Tapered fiber probe-based optical cardiac pacemaker.Frontiers in bioengineering and biotechnology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Judith S LangenInstitute of Physiology I, Medical Faculty, University of Bonn, Bonn, Germany.ORCID 0009-0002-8823-3660
Patrick M BoyleDepartment of Bioengineering, University of Washington, Seattle, Washington, USA.ORCID 0000-0001-9048-1239
Daniela MalanInstitute of Physiology I, Medical Faculty, University of Bonn, Bonn, Germany.ORCID 0000-0001-9034-6555
Philipp SasseInstitute of Physiology I, Medical Faculty, University of Bonn, Bonn, Germany.ORCID 0000-0002-8502-9472

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Increased cardiac excitability and reduced electrical coupling promote cardiac arrhythmia and can be quantified by input resistance (

Indexed as

Arrhythmias, CardiacHeartMyocytes, CardiacOptogeneticsAction PotentialsAnimalsMicePotassium Channels, Inwardly RectifyingPotassium Channels, Inwardly Rectifying

Identifiers

PMID40020054
PMCPMC11870084

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.