Evidence map›Paper›PMID 40019928›Full record

ArticlePLOS global public health2025

"A man never cries": A mixed-methods analysis of gender differences in depression and alcohol use in Moshi, Tanzania.

Alena Pauley, Mia Buono, Madeline Metcalf, Kirstin West, Sharla Rent, William Nkenguye, Yvonne Sawe, Mariana Mikindo, Joseph Kilasara, Judith Boshe and 3 more

Abstract read
In one paragraph

Article in PLOS global public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

  • Update of
    "2023
5 · Who and what money

Authors and funding

13 authors.

Alena PauleyDuke Global Health Institute, Duke University, Durham, North Carolina, United States of America.ORCID https://orcid.org/0000-0002-7489-7469
Mia BuonoDuke Global Health Institute, Duke University, Durham, North Carolina, United States of America.ORCID https://orcid.org/0000-0001-7317-9492
Madeline MetcalfDuke Global Health Institute, Duke University, Durham, North Carolina, United States of America.
Kirstin WestDuke Global Health Institute, Duke University, Durham, North Carolina, United States of America.ORCID https://orcid.org/0000-0002-5009-0513
Sharla RentDuke Global Health Institute, Duke University, Durham, North Carolina, United States of America.ORCID https://orcid.org/0000-0002-8577-478X
William NkenguyeKilimanjaro Christian Medical University College, Moshi, Tanzania.ORCID https://orcid.org/0000-0003-4322-7937
Yvonne SaweKilimanjaro Clinical Research Institute, Moshi, Tanzania.
Mariana MikindoKilimanjaro Clinical Research Institute, Moshi, Tanzania.
Joseph KilasaraKilimanjaro Clinical Research Institute, Moshi, Tanzania.
Judith BosheKilimanjaro Clinical Research Institute, Moshi, Tanzania.ORCID https://orcid.org/0000-0002-1684-7295
Brandon A KnettelDuke Global Health Institute, Duke University, Durham, North Carolina, United States of America.ORCID https://orcid.org/0000-0003-2986-1579
Blandina T MmbagaDuke Global Health Institute, Duke University, Durham, North Carolina, United States of America.
Catherine A StatonDuke Global Health Institute, Duke University, Durham, North Carolina, United States of America.ORCID https://orcid.org/0000-0002-6468-2894

Funding

PRACT: A Pragmatic Randomized Adaptive Clinical Trial to Investigate Controlling Alcohol related harms in a Low-Income Setting; Emergency Department Brief Interventions in TanzaniaR01AA027512 · NIAAA · DUKE UNIVERSITY · PI STATON, CATHERINE ANN · 2020 to 2024
$3.1M
The TRECK Program: Trauma REsearch Capacity Building in Kilimanjaro, TanzaniaD43TW012205 · FIC · KILIMANJARO CHRISTIAN MEDICAL CENTRE · PI MMBAGA, BLANDINA THEOPHIL, STATON, CATHERINE ANN · 2021 to 2025
$1.5M
FIC NIH HHS D43 TW012205NIAAA NIH HHS R01 AA027512
6 · The paper itself

Abstract

Globally, gender differences are well-documented in alcohol use behaviors and MDD, yet these remain understudied in Moshi, Tanzania. Understanding gender-specific nuances of these conditions is crucial for developing effective and culturally appropriate mental health treatments. This study aims to investigate gender differences in MDD, alcohol use, and other aspects of mental well-being among patients at Kilimanjaro Christian Medical Centre (KCMC). Six hundred and seventy-six patients presenting for care at the KCMC Emergency Department (ED) and Reproductive Health Centre (RHC) were enrolled between October 2021 and May 2022. Patients were selected through systematic random sampling and completed quantitative surveys, including the Alcohol Use Disorder Identification Test (AUDIT) and the Patient Health Questionnaire 9 (PHQ-9). Nineteen patients were purposively chosen from the study population for in-depth interviews (IDIs) exploring alcohol use, gender, and depression. ANOVA, chi-squared tests, adjusted log-binomial regressions, and a linear regression model were used to analyze quantitative data in RStudio. A grounded theory approach was used to analyze all IDIs in NVivo. Average [SD] PHQ-9 scores were 7.22 [5.07] for ED women, 4.91 [4.11] for RHC women, and 3.75 [4.38] among ED men. ED women held the highest prevalence of MDD (25%) compared to RHC women (11%) and ED men (7.9%) (p < 0.001). Depressive symptoms were associated with higher AUDIT scores for ED men (R2 = 0.11, p < 0.001). Qualitative analysis showed that while present for women, social support networks were notably absent for men, playing a role in alcohol use. For men, alcohol was described as a coping mechanism for stress. Intersectionality of gender, alcohol use, and depression is influenced by sociocultural and behavioral norms in Moshi. As such, multi-layered, gender-differentiated programming should be considered for the treatment of substance use and mental health conditions in this region.

Identifiers

PMID40019928
PMCPMC11870386

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.