Evidence map›Paper›PMID 40019840›Full record

ArticlePhysiological reports2025

Comparing methods to measure the dispersion of breathing parameters during exercise testing: A simulation study based on real-life parameters from patients with dysfunctional breathing.

Léon Genecand, Cyril Jaksic, Roberto Desponds, Gaëtan Simian, Ivan Guerreiro, Sara Thorens, Marco Altarelli, Isabelle Frésard, Chloé Cantero, Aurélien Bringard and 6 more

Abstract readComparative Study
In one paragraph

Article in Physiological reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Léon GenecandService de Pneumologie, Département de Médecine, Hôpitaux Universitaires de Genève, Genève, Switzerland.ORCID https://orcid.org/0000-0001-6965-0480
Cyril JaksicCentre de Recherche Clinique, Hôpitaux Universitaires de Genève, Genève, Switzerland.
Roberto DespondsFaculté de Mathématique, Université de Genève, Genève, Switzerland.
Gaëtan SimianFaculté de Mathématique, Université de Genève, Genève, Switzerland.
Ivan GuerreiroService de Pneumologie, Département de Médecine, Hôpitaux Universitaires de Genève, Genève, Switzerland.
Sara ThorensFaculté de Médecine, Université de Genève, Genève, Switzerland.
Marco AltarelliService de Pneumologie, Hôpital du Valais, Centre Hospitalier du Valais Romand, Sion, Switzerland.
Isabelle FrésardService de Pneumologie, Hôpital du Valais, Centre Hospitalier du Valais Romand, Sion, Switzerland.
Chloé CanteroService de Pneumologie, Département de Médecine, Hôpitaux Universitaires de Genève, Genève, Switzerland.
Aurélien BringardService de Pneumologie, Département de Médecine, Hôpitaux Universitaires de Genève, Genève, Switzerland.
Antoine BeurnierUniversité Paris-Saclay, School of Medicine, Le Kremlin-Bicêtre, France.
Pierantonio LavenezianaAP-HP, Groupe Hospitalier Universitaire APHP-Sorbonne Université, Hôpitaux Pitié-Salpêtrière, Saint-Antoine et Tenon, Service Des Explorations Fonctionnelles de la Respiration, de l'Exercice et de la Dyspnée (Département R3S), Paris, France.
David MontaniUniversité Paris-Saclay, School of Medicine, Le Kremlin-Bicêtre, France.
Anne BergeronService de Pneumologie, Département de Médecine, Hôpitaux Universitaires de Genève, Genève, Switzerland.
Frédéric LadorFaculté de Médecine, Université de Genève, Genève, Switzerland.
Pierre-Olivier BridevauxFaculté de Médecine, Université de Genève, Genève, Switzerland.

Funding

Fondation LancardisLigue Pulmonaire GenevoiseLigue Pulmonaire ValaisanneThe Fondation Rankers Hartmann
6 · The paper itself

Abstract

The dispersion of the tidal volume and of the breathing frequency have been used to diagnose dysfunctional breathing during cardio-pulmonary exercise testing. No validated methods to objectively describe this dispersion exist. We aimed to validate such a method. We used simulations based on real-life parameters. Moving standard deviation (MSD) and residuals from locally estimated scatterplot smoothing (LOESS) were evaluated. The precision and the bias of each tested method at rest and during exercise simulations, with and without sighs, were measured. For LOESS, a 2nd degree polynomial was used, and different spans were tested (LOESS

Indexed as

Exercise TestRespirationRespiration DisordersAdultComputer SimulationFemaleHumansMaleMiddle AgedTidal Volumeabnormal breathing patterncardio‐pulmonary exercise testingdispersiondysfunctional breathingsimulations

Identifiers

PMID40019840
PMCPMC11870078

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.