Evidence map›Paper›PMID 40019798›Full record

ArticlePhysiological genomics2025

Evidence of a novel gene locus

Siyu Wang, Petra Lenzini, Bharat Thyagarajan, Joseph H Lee, Badri N Vardarajan, Anatoli Yashin, Iva Miljkovic, E Warwick Daw, Shiow J Lin, Gary J Patti and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiological genomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Siyu WangDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States.
Petra LenziniDepartment of Radiology, Washington University School of Medicine, St. Louis, Missouri, United States.
Bharat ThyagarajanDepartment of Laboratory Medicine and Pathology, School of Medicine, University of Minnesota, Minneapolis, Minnesota, United States.
Joseph H LeeGertrude H. Sergievsky Center and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Departments of Neurology and Epidemiology, Columbia University Medical Center, New York City, New York, United States.ORCID 0000-0002-2000-4821
Badri N VardarajanGertrude H. Sergievsky Center and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Departments of Neurology and Epidemiology, Columbia University Medical Center, New York City, New York, United States.
Anatoli YashinSocial Science Research Institute, Duke University, Durham, North Carolina, United States.
Iva MiljkovicDepartment of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.ORCID 0000-0002-3155-9777
E Warwick DawDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States.
Shiow J LinDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States.
Gary J PattiDepartment of Chemistry, Washington University School of Arts & Sciences, St. Louis, Missouri, United States.
Michael R BrentDepartment of Computer Science & Engineering, McKelvey School of Engineering, Washington University, St. Louis, Missouri, United States.
Joseph M ZmudaDepartment of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.
Thomas T PerlsDepartment of Medicine, Section of Geriatrics, Boston Medical Center, Boston University School of Medicine, Boston, Massachusetts, United States.
Kaare ChristensenUnit of Epidemiology, Biostatistics, and Biodemography, Department of Public Health, Southern Denmark University, Odense, Denmark.
Michael A ProvinceDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States.
Ping AnDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States.ORCID 0000-0001-6162-8780

Funding

The Long Life Family StudyU19AG063893 · NIA · WASHINGTON UNIVERSITY · PI PAOLA SEBASTIANI · 2019 to 2026
$125.4M
Long Life Family Study: Data Management and Coordinating CenterU01AG023746 · NIA · WASHINGTON UNIVERSITY · PI PROVINCE, MICHAEL A. · 2004 to 2018
$29.2M
The Long Life Family StudyU01AG023755 · NIA · BOSTON MEDICAL CENTER · PI PERLS, THOMAS T · 2004 to 2018
$13.2M
Plasma beta-amyloid in long lived families: genetics and risk of ADU01AG023749 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI COSENTINO, STEPHANIE ANN, LEE, JOSEPH HYUNGWOO · 2004 to 2018
$13.0M
Multicenter Study on Exceptional Survival in Families: The Long Life Family StudyU01AG023744 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NEWMAN, ANNE B., ZMUDA, JOSEPH M. · 2004 to 2018
$12.0M
Long Life Family Study: Duke Univ./Univ. of Southern Denmark Field CenterU01AG023712 · NIA · DUKE UNIVERSITY · PI CHRISTENSEN, KAARE · 2004 to 2018
$10.4M
HHS | NIH | National Institute on Aging (NIA) U01AG023746NIA NIH HHS U01 AG023712NIA NIH HHS U01 AG023744NIA NIH HHS U01 AG023746NIA NIH HHS U01 AG023749NIA NIH HHS U01 AG023755NIA NIH HHS U19 AG063893
6 · The paper itself

Abstract

Glycated hemoglobin A1c (HbA1c) indicates average glucose levels over 3 mo and is associated with insulin resistance and type 2 diabetes (T2D). Longitudinal change in circulating HbA1c (ΔHbA1c) is also associated with aging processes, cognitive performance, and mortality. We analyzed ΔHbA1c in 1,886 nondiabetic Europeans from the Long Life Family Study (LLFS) to uncover gene loci influencing ΔHbA1c. Using growth curve modeling adjusted for multiple covariates, we derived ΔHbA1c and conducted linkage-guided sequence analysis. Our genome-wide linkage scan identified a significant locus on

Indexed as

Genetic LociGlycated HemoglobinGTPase-Activating ProteinsLongevityAgedDiabetes Mellitus, Type 2FemaleGenetic LinkageGenome-Wide Association StudyHumansLongitudinal StudiesMaleMiddle AgedPolymorphism, Single NucleotideGlycated HemoglobinGTPase-Activating Proteinshemoglobin A1c protein, humanARHGAP44family members without diabetesglycated hemoglobin A1clinkage-guided sequence and multi-omics data analysis

Identifiers

PMID40019798
PMCPMC12182963

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.