Trial reportClinical and experimental nephrology2025
Association of the single nucleotide polymorphism rs1697421 with an increased postprandial serum phosphorus level.
Trial report in Clinical and experimental nephrology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
backgroundA high serum phosphorus (P) level is a risk factor for cardiovascular disease (CVD) and mortality in patients with chronic kidney disease (CKD). Moreover, increased postprandial serum P levels after high dietary P intake impair vascular endothelial function. Therefore, management of postprandial serum P levels is important in CKD patients. Recently, a genome-wide association study identified single nucleotide polymorphisms (SNPs) associated with fasting serum P levels in individuals of European ancestry. However, the effects of these SNPs on postprandial serum P levels and vascular endothelial function remain unclear.
methodsA randomized, single-blind, crossover study in 99 healthy Japanese was performed to determine the association between SNPs and postprandial serum P levels, flow-mediated dilation (FMD) or alkaline phosphatase activity. The impact of SNP on gene transcriptional activity was also analyzed using in vitro experiment.
resultsThe participants who were TT homozygotes of SNP rs1697421 (located near the tissue nonspecific alkaline phosphatase [TNAP] gene) had higher postprandial serum P levels than C allele carriers. FMD was more significantly impaired in the TT homozygotes than in the CC homozygotes in men. In the in vitro experiment, TNAP transcriptional activity was significantly lower in TT homozygotes than in the others.
conclusionThese results suggest that in TT homozygotes of SNP rs1697421, hepatic P uptake is affected through changes in serum TNAP levels, leading to high postprandial serum P levels and impairment of FMD. The present findings can contribute to the development of gene-based therapeutic approaches for the management of serum P levels.
Indexed as
Identifiers
40019722What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.