ArticleNeurochemical research2025
Infant Maltreatment Induces Early Alterations in Adrenal Glands and Stress Response in Juvenile Rat Offspring.
Article in Neurochemical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Chronic stressors, such as infant maltreatment during early development, can have long-lasting effects on an individual's health and stress-coping abilities across the lifespan. In this study, we applied the scarcity-adversity model (SAM) to Wistar rats from postnatal days (PND) 8 to 12 to evaluate the impact of scarcity condition on adrenal glands morphology and stress response in juvenile offspring (PND 21-35) of both sexes. Our results demonstrate that SAM exposure leads to significant alterations in the adrenal glands of offspring. Notably, the cortex-to-medulla ratio was reduced in SAM pups starting at PND 28. Morphological analysis of the adrenal cortex revealed an increased thickness of the undifferentiated zone, suggesting enhanced cell proliferation, alongside a transient reduction in the thickness of the zona fasciculata, where glucocorticoid-synthesizing cells are located. Additionally, we observed a reduction in the cytoplasmic diameter of zona fasciculata cells, coupled with an increase in the thickness of blood capillaries in this region in SAM offspring of both sexes. An increase in BrdU
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