ArticleReproductive sciences (Thousand Oaks, Calif.)2025
Role of Immune Cells in Mediating the Effect of Lipids on Preeclampsia.
Article in Reproductive sciences (Thousand Oaks, Calif.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
Lipidomes are thought to be associated with preeclampsia (PE). In addition, the immune response has been reported to play an important role in the development of PE. However, the causal relationship between the three remains unclear. We aimed to determine whether genetically predicted lipidomes, immunophenotypes, have a causal effect on PE, and also to explore whether immunophenotypes mediate the causal effect of lipidomes on PE. Two-step Mendelian randomization (MR) analysis, mainly using the inverse variance weighted (IVW) method, was performed to estimate the correlation between lipidomes, immunophenotypes, and PE and the potential effect of mediators. Bayesian analysis was also performed to improve the accuracy of the results. Finally, heterogeneity and horizontal polytropy tests were performed. The STROBE-MR checklist for the reporting of MR studies was used in this study. A total of 9 lipidomes and 25 immunophenotypes were found to be causally associated with the risk of PE, and mediation MR analyses identified HLA DR + Natural Killer %Natural Killer, HLA DR on B cell, and CD28 + CD45RA + CD8
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