Evidence map›Paper›PMID 40019609›Full record

ArticleBiochemical genetics2026

Downregulation of RORl via STAT3 and P300 Promotes P38 Pathway- Dependent Lens Epithelial Cells Apoptosis in Age-Related Cataract.

Yue Zhang, Yuzhu Hu, Dongmei Su, Yanjiang Fu, Xiaoya Chen, Xiao Zhang, Shunfei Zheng, Xu Ma, Shanshan Hu

Abstract read
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In one paragraph

Article in Biochemical genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yue Zhang *Mudanjiang Medical University, Mudanjiang, 157011, China.
Yuzhu Hu *Mudanjiang Medical University, Mudanjiang, 157011, China.
Dongmei SuMudanjiang Medical University, Mudanjiang, 157011, China.
Yanjiang FuDaqing Ophthalmology Hospital, Daqing, 163711, China.
Xiaoya ChenMudanjiang Medical University, Mudanjiang, 157011, China.
Xiao ZhangMudanjiang Medical University, Mudanjiang, 157011, China.
Shunfei ZhengMudanjiang Medical University, Mudanjiang, 157011, China.
Xu MaDepartment of Genetics, Health Department, National Research Institute for Family Planning, Beijing, 100081, China. jswkysgc@126.com.
Shanshan HuHongqi Hospital of Mudanjiang Medical University, Mudanjiang, 157011, China. hushanshan19830219@126.com.

Funding

the Heilongjiang Provincial Undergraduate Colleges and Universities Central to Support the Reform and Development of Local Colleges and Universities 2020YQ08the National Natural Science Foundation of China 82271070the Natural Science Foundation Project of Heilongjiang Province LH2021H112
6 · The paper itself

Abstract

Lens Epithelial Cells (LECs) apoptosis is a critical driving factor of age-related cataract (ARC), but the specific molecular mechanisms remain undefined. Herein, a novel target of ROR1 regulation was identified, the mechanism was elucidated by which ROR1 and its associated pathway proteins influence hydrogen peroxide (H

Indexed as

ApoptosisCataractE1A-Associated p300 ProteinEpithelial CellsLens, Crystallinep38 Mitogen-Activated Protein KinasesReceptor Tyrosine Kinase-like Orphan ReceptorsSTAT3 Transcription FactorAgedAnimalsCell LineDown-RegulationHumansHydrogen PeroxideMaleMAP Kinase Signaling SystemE1A-Associated p300 ProteinEP300 protein, humanHydrogen Peroxidep38 Mitogen-Activated Protein KinasesReceptor Tyrosine Kinase-like Orphan ReceptorsROR1 protein, humanSTAT3 protein, humanSTAT3 Transcription FactorAge-related cataractApoptosisLens epithelial cellsP300ROR1STAT3

Identifiers

PMID40019609

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.