Evidence map›Paper›PMID 40019596›Full record

ArticleFunctional & integrative genomics2025

Immunomodulatory effects of traditional chinese medicine on cancer: insights from network pharmacology and single-cell RNA sequencing data on the treatment of lung adenocarcinoma with shenling baizhu powder.

Xianqiang Zhou, Jiameng Gao, Yixin Zhang, Cuiling Feng

Abstract read
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In one paragraph

Article in Functional & integrative genomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Xianqiang Zhou *Department of Traditional Chinese Medicine, Peking University People's Hospital, Beijing, 100032, China.
Jiameng Gao *Department of Respiratory and Critical Care Medicine, Shanghai Pudong Hospital, Fudan University, Shanghai, 201399, China.
Yixin Zhang *Department of Traditional Chinese Medicine, Peking University People's Hospital, Beijing, 100032, China.
Cuiling FengDepartment of Traditional Chinese Medicine, Peking University People's Hospital, Beijing, 100032, China. fengcuiling@pkuph.edu.cn.

Funding

Beijing Key Specialty Project for Major Epidemic Prevention and Control No. 2022-ZX-10Beijing Major Difficult and Complicated Disease Collaborative Project of Integrative Chinese and Western Medicine No. 2023BJSZDYNJBXTGG-055
6 · The paper itself

Abstract

Shenling Baizhu Powder (SLBZP), commonly used as a complementary and alternative therapy for lung adenocarcinoma (LUAD), is believed to enhance patients' immune function. However, its underlying mechanisms remain unclear. By integrating network pharmacology and single-cell RNA sequencing (scRNA-seq) data, the study investigates the immune therapeutic effects of SLBZP in LUAD. Immune infiltration landscape analysis revealed significant differences in immune cell infiltration levels between normal and LUAD groups. ScRNA-seq analysis showed that LUAD progression was associated with an increased abundance of macrophage infiltration, and the characteristics of 13 macrophage clusters were closely related to target genes. Using machine learning, we identified 4 macrophage-related gene sets associated with LUAD: ALOX5, IL2RA, MMP9, and PPARG. Immune infiltration analysis demonstrated a strong correlation between these target genes and immune responses. Molecular docking results indicated that SLBZP could modulate these target genes through various bioactive compounds, indirectly affecting macrophages to enhance the immune system's functional state. This study provides new insights into the role of tonifying TCM formulas in tumor immune modulation and offers theoretical support for future clinical research.

Indexed as

Adenocarcinoma of LungDrugs, Chinese HerbalLung NeoplasmsGene Expression Regulation, NeoplasticHumansMacrophagesMedicine, Chinese TraditionalMolecular Docking SimulationNetwork PharmacologySequence Analysis, RNASingle-Cell AnalysisBaizhuDrugs, Chinese HerbalLung adenocarcinoma (LUAD)Molecular dockingNetwork pharmacologyShenling baizhu powder (SLBZP)Single-cell RNA sequencing (scRNA-seq)

Identifiers

PMID40019596

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.