Evidence map›Paper›PMID 40019579›Full record

Observational studySupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2025

Impact of anxiety and chemotherapy side effects on quality of life in patients with malignant lymphoma.

Yuta Teshigawara, Kazuhide Tanaka, Tomoya Tachi, Masataka Shishido, Seiji Inoue, Teppei Makino, Yoshihiro Noguchi, Junichi Kitagawa, Takashi Mizui, Hitomi Teramachi and 3 more

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yuta TeshigawaraLaboratory of Clinical Pharmacy, Gifu Pharmaceutical University, 1-25-4, Daigakunishi, Gifu, 501-1113, Japan.
Kazuhide TanakaDepartment of Pharmacy, Gifu Municipal Hospital, 7-1, Kashima-Cho, Gifu, 500-8513, Japan.ORCID http://orcid.org/0000-0002-9433-0603
Tomoya TachiLaboratory of Clinical Pharmacy, Gifu Pharmaceutical University, 1-25-4, Daigakunishi, Gifu, 501-1113, Japan. tachi@phar.nagoya-cu.ac.jp.ORCID http://orcid.org/0000-0002-5380-0218
Masataka ShishidoLaboratory of Clinical Pharmacy, Gifu Pharmaceutical University, 1-25-4, Daigakunishi, Gifu, 501-1113, Japan.
Seiji InoueDepartment of Pharmacy, Gifu Municipal Hospital, 7-1, Kashima-Cho, Gifu, 500-8513, Japan.
Teppei MakinoDepartment of Pharmacy, Gifu Municipal Hospital, 7-1, Kashima-Cho, Gifu, 500-8513, Japan.
Yoshihiro NoguchiLaboratory of Clinical Pharmacy, Gifu Pharmaceutical University, 1-25-4, Daigakunishi, Gifu, 501-1113, Japan.ORCID http://orcid.org/0000-0002-9110-9604
Junichi KitagawaDepartment of Hematology, Gifu Municipal Hospital, 7-1, Kashima-Cho, Gifu, 500-8513, Japan.
Takashi MizuiLaboratory of Clinical Pharmacy, Gifu Pharmaceutical University, 1-25-4, Daigakunishi, Gifu, 501-1113, Japan.
Hitomi TeramachiLaboratory of Clinical Pharmacy, Gifu Pharmaceutical University, 1-25-4, Daigakunishi, Gifu, 501-1113, Japan.
Masahiro YasudaDepartment of Pharmacy, Gifu Municipal Hospital, 7-1, Kashima-Cho, Gifu, 500-8513, Japan.ORCID http://orcid.org/0000-0003-4119-0149
Tomoaki YoshimuraLaboratory of Clinical Pharmacy, Gifu Pharmaceutical University, 1-25-4, Daigakunishi, Gifu, 501-1113, Japan.ORCID http://orcid.org/0009-0008-2486-8169
Senji KasaharaLaboratory of Pharmaceutical Health Care and Promotion, Gifu Municipal Hospital, 7-1, Kashima-Cho, Gifu, 500-8513, Japan.ORCID http://orcid.org/0000-0002-1784-2402

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThere are no reports on the side effects of chemotherapy on the quality of life (QOL) of patients with malignant lymphoma or on the intensity of anxiety affecting these side effects. We conducted a prospective observational study to evaluate the association between anxiety, chemotherapy side effects, and QOL in patients with malignant lymphoma undergoing their first cancer chemotherapy treatment.

methodsWe studied anxiety intensity, side effects, and QOL changes in 60 patients with malignant lymphoma who received their first course of initial chemotherapy at Gifu Municipal Hospital (Japan) between January 2021 and December 2022. Questionnaires were administered before and after the first chemotherapy course. The questionnaires included patient information and the STAI-JYZ, EQ-5D-5L, and EORTC QLQ-C30. EQ-5D-5L utility values and EORTC QLQ-C30 item scores were compared before and after the first chemotherapy course. The proportion of patients with issues with the five EORTC QLQ-C30 items was compared before and after the first chemotherapy. QOL was compared based on side effects and severity. QOL based on anxiety intensity was also compared.

resultsThe number of patients reporting problems with their usual activities significantly increased after the first chemotherapy course. Emotional functioning on the EORTC QLQ-C30 significantly increased after the first chemotherapy course. Patients' anxiety, depression, and pain decreased after the first course of chemotherapy. Patients with anorexia had lower utility values and EORTC QLQ-C30 Global health status. The utility values of the anxiety group increased significantly after chemotherapy.

conclusionChemotherapy reduced activity but improved mental and psychological status. Anorexia negatively affects QOL and improves the QOL of patients with anxiety undergoing chemotherapy. This study clarified the relationship between anxiety, side effects, and QOL associated with cancer chemotherapy in patients with malignant lymphoma.

Indexed as

Antineoplastic AgentsAnxietyLymphomaQuality of LifeAdultAgedAged, 80 and overFemaleHumansJapanMaleMiddle AgedProspective StudiesSurveys and QuestionnairesAntineoplastic AgentsAnorexiaAnxietyChemotherapyEORTC QLQ-C30Malignant lymphomaQuality of life

Identifiers

PMID40019579

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.