ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025
Morphology Effect of Puffball Spores on Hemostasis: A Promising Solution for Hemostatic Challenges.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- A cell motility-based selective hydrogel enables rapid generation of nerve-repairing blood clots.Bioactive materials · 2026Article
- Bench-to-Bedside Translation of Self-Healing Colloidal Hydrogels as Next Generation Design of Flowable Hemostatic Matrix: From Preclinical Evaluation to Human Clinical Trials.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Morphology Effect of Puffball Spores on Hemostasis: A Promising Solution for Hemostatic Challenges.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
Hemostatic materials play a crucial role in wound healing by promoting blood concentration or releasing procoagulant factors. While hydrophilic hemostatic materials are effective, they may cause excessive blood loss and difficulty removing from the wound. Conversely, hydrophobic hemostatic materials avoid these issues but may hinder blood concentration and the release of procoagulant factors due to their water-repellent nature. This study investigates the hemostatic properties and underlying mechanism of puffball (Bovistella sp.) spores, a traditional hemostatic material. The unique hollow ball-rod morphology and strong water affinity of puffball spores enable efficient water removal, leading to improved blood clotting without the drawbacks typically associated with hydrophilic hemostatic materials. Further analysis reveals that the nano-protrusions on the spore surface create a textured hydrophobic surface due to the pinning effect, which prevents adhesion to the wound after clotting. Overall, puffball spores exhibit hemostatic efficacy comparable to the commercial agent QuikClot, with enhanced safety and reduced side effects. Their characteristic morphology, physicochemical properties, and chemical compositions offer inspiration for advancing hemostatic materials and addressing current challenges in wound healing. Additionally, this work provides new perspectives for insight into the pharmacological substance basis of traditional medicine, expanding beyond the conventional component-focused mentality to a material-based insight.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.