Evidence map›Paper›PMID 40019141›Full record

ArticleeLife2025

Adaptive chunking improves effective working memory capacity in a prefrontal cortex and basal ganglia circuit.

Aneri Soni, Michael J Frank

Abstract read
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Aneri SoniBrown University, Providence, United States.ORCID https://orcid.org/0000-0001-6410-8414
Michael J FrankBrown University, Providence, United States.ORCID https://orcid.org/0000-0001-8451-0523

Funding

Cognitive Neurocomputational Task Reliability and Clinical Applications ConsortiumR01MH084840 · NIMH · WASHINGTON UNIVERSITY · PI Deanna Barch, Cameron S. Carter · 2008 to 2026
$8.5M
Interdisciplinary Predoctoral Neuroscience Training Program in the Neuroscience Graduate Program.T32MH020068 · NIMH · BROWN UNIVERSITY · PI LIPSCOMBE, DIANE, SHEINBERG, DAVID L · 1999 to 2025
$7.6M
Training Program for Interactionist Cognitive Neuroscience (ICoN)T32MH115895 · NIMH · BROWN UNIVERSITY · PI MICHAEL J. FRANK, STEPHANIE Ruggiano JONES · 2019 to 2026
$1.8M
Brain Science Compute ClusterS10OD025181 · OD · BROWN UNIVERSITY · PI SANES, JEROME N · 2019 to 2019
$600k
NIH HHS S10 OD025181NIH Office of the Director S10OD025181NIMH NIH HHS R01 MH084840NIMH NIH HHS R01 MH084840-08A1NIMH NIH HHS T32 MH020068NIMH NIH HHS T32 MH115895NIMH NIH HHS T32MH115895Office of Naval Research N00014-23-1-2792
6 · The paper itself

Abstract

How and why is working memory (WM) capacity limited? Traditional cognitive accounts focus either on limitations on the number or items that can be stored (slots models), or loss of precision with increasing load (resource models). Here, we show that a neural network model of prefrontal cortex and basal ganglia can learn to reuse the same prefrontal populations to store multiple items, leading to resource-like constraints within a slot-like system, and inducing a trade-off between quantity and precision of information. Such 'chunking' strategies are adapted as a function of reinforcement learning and WM task demands, mimicking human performance and normative models. Moreover, adaptive performance requires a dynamic range of dopaminergic signals to adjust striatal gating policies, providing a new interpretation of WM difficulties in patient populations such as Parkinson's disease, ADHD, and schizophrenia. These simulations also suggest a computational rather than anatomical limit to WM capacity.

Indexed as

Basal GangliaMemory, Short-TermPrefrontal CortexHumansModels, Neurologicalbasal ganglia networkchunkingcredit assignmentneural networkneurosciencenoneprefrontal cortexworking memory

Identifiers

PMID40019141
PMCPMC11870651

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.