ArticleeLife2025
Bridging the 3D geometrical organisation of white matter pathways across anatomical length scales and species.
Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Intricate mesoscale organization of the anterior commissure in the rhesus monkey, with implications for neuroimaging.Brain structure & function · 2026Article
- Mechanisms of transcranial magnetic brain stimulation.Physiological reviews · 2026Review
- High-Definition Brain Network (HDBN) Delineation of CDKL5 Deficiency Disorder (CDD) in Genetically Engineered Mice.Biomolecules · 2026Article
- Bridging the microstructural gap in human connectomics using hierarchical phase-contrast tomography as a reference for diffusion MRI in the human brain.bioRxiv : the preprint server for biology · 2026Article
- What needs to be standardized for reliable, reproducible, and robust tractography?GigaScience · 2026Review
- Reconstructing the human brain's wiring diagram from axons up.Trends in neurosciences · 2026Review
- Nondestructive X-ray tomography of brain tissue ultrastructure.Nature methods · 2025Article
- Myelin water and tensor-valued diffusion imaging: (How) are they related?Magnetic resonance in medicine · 2025Article
- Rethinking tractography and neuroanatomy: does image resolution hold the key?Brain structure & function · 2025Article
- Millennium Pathways for Tractography: 40 grand challenges to shape the future of tractography.ArXiv · 2025Article
- Considerations and recommendations from the ISMRM Diffusion Study Group for preclinical diffusion MRI: Part 3-Ex vivo imaging: Data processing, comparisons with microscopy, and tractography.Magnetic resonance in medicine · 2025Review
- Brain connectivity: complex, not chaotic.Brain structure & function · 2025Article
- Axonal structure-function relationships across experimental modalities.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Synchrotron X-ray imaging of soft biological tissues - principles, applications and future prospects.Journal of cell science · 2024Review
- Exploring white matter dynamics and morphology through interactive numerical phantoms: the White Matter Generator.Frontiers in neuroinformatics · 2024Article
Corrections and comments
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Authors and funding
16 authors.
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Abstract
We used diffusion MRI and x-ray synchrotron imaging on monkey and mice brains to examine the organisation of fibre pathways in white matter across anatomical scales. We compared the structure in the corpus callosum and crossing fibre regions and investigated the differences in cuprizone-induced demyelination in mouse brains versus healthy controls. Our findings revealed common principles of fibre organisation that apply despite the varying patterns observed across species; small axonal fasciculi and major bundles formed laminar structures with varying angles, according to the characteristics of major pathways. Fasciculi exhibited non-straight paths around obstacles like blood vessels, comparable across the samples of varying fibre complexity and demyelination. Quantifications of fibre orientation distributions were consistent across anatomical length scales and modalities, whereas tissue anisotropy had a more complex relationship, both dependent on the field-of-view. Our study emphasises the need to balance field-of-view and voxel size when characterising white matter features across length scales.
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