Evidence map›Paper›PMID 40018818›Full record

ArticleAdvanced materials (Deerfield Beach, Fla.)2025

Development of Bioorthogonally Degradable Tough Hydrogels Using Enamine N-Oxide Based Crosslinkers.

Thomas T Kim, Deep Malu, Dongjing He, Yuhang Hu, Justin Kim

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced materials (Deerfield Beach, Fla.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. On-Demand Chemically Degradable Hydrogels for Biological Applications.Chembiochem : a European journal of chemical biology · 2026
    Review
  3. Nonmonotonic rate-dependent adhesion of hydrogels.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Thomas T KimSchool of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA, 30332, USA.ORCID https://orcid.org/0009-0009-5538-9053
Deep MaluGeorge W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA, 30332, USA.
Dongjing HeGeorge W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA, 30332, USA.
Yuhang HuGeorge W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA, 30332, USA.
Justin KimSchool of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA, 30332, USA.ORCID https://orcid.org/0000-0002-4076-2005

Funding

Division of Chemistry 2238040Division of Chemistry 2503344National Science Foundation 2238040National Science Foundation 2503344
6 · The paper itself

Abstract

Inducibly degradable polymers present new opportunities to integrate tough hydrogels into a wide range of biomaterials. Rapid and inducible degradation enables fast transition in material properties without sacrificing material integrity prior to removal. In pursuit of bioorthogonal chemical modalities that will enable inducible polymer degradation in biologically relevant environments, enamine N-oxide crosslinkers are developed for double network acrylamide-based polymer/alginate hydrogels. Bioorthogonal dissociation initiated by the application of aqueous diboron solution through several delivery mechanisms effectively lead to polymer degradation. Their degradation by aqueous B

Indexed as

Acrylic ResinsAlginatesAnimalsBiocompatible MaterialsHydrogelsMiceAcrylic ResinsAlginatesBiocompatible MaterialsHydrogelspoly-N-isopropylacrylamidebioorthogonaldegradabledouble network hydrogelsenamine N‐oxidesintraoral wound dressingstough hydrogels

Identifiers

PMID40018818
PMCPMC11962699

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.