Observational studyJournal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG2025
Optical super-high magnification dermoscopy of benign and malignant melanocytic lesions in correlation with histopathology.
Observational study in Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- A deep learning-based radiomics model for noninvasive diagnosis of melanoma.Melanoma research · 2026Article
- Magnified Dermoscopy in Skin Cancer and Infectious Skin Diseases.Medicina (Kaunas, Lithuania) · 2025Review
- Optical super-high magnification dermoscopy of benign and malignant melanocytic lesions in correlation with histopathology.Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG · 2025Observational
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesTechnical advances have allowed for significant improvements in imaging techniques in recent years. Specifically, lesions can now be depicted at a much higher magnification - up to 400 x - using optical super-high magnification dermoscopy (OSHMD). PATIENTS AND
methodsThis is a retrospective, observational study assessing 99 melanocytic lesions in patients from the University Hospital Heidelberg. Dermoscopy (20 x) and OSHMD images (90 x, 120 x, 150 x, 180 x and 270 x) were acquired. OSHMD images were assessed for the presence/absence of pigment network, distribution, size and color of cells, dots and roundish nests (small/large), structureless areas and vessels in nevi versus melanomas. Correlation studies with histopathology were performed.
resultsWe found that in OSHMD atypical pigment network, irregular dark dots, atypical vessels and irregular grey out-of-focus cells are clues to melanoma. Black dots and small roundish nests in OSHMD images corresponded to nests of atypical melanocytes in melanomas in histopathology. Grey out-of-focus cells in OSHMD images corresponded to melanophages in histopathology and in irregular distribution were found more frequently in melanomas.
conclusionsWe conclude that knowing about histopathological correlates OSHMD may support differentiating nevi from melanomas.
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