ArticleCureus2025
Sarcoidosis With Generalized Lymphadenopathy: A Clinical Mimic of Lymphoma.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sarcoidosis is a multiorgan disease characterized by noncaseating granulomatous lesions, most commonly affecting the lungs. It typically presents with cough, dyspnea, wheezing, and chest pain. Chest X-rays often show bilateral hilar adenopathy. Extrapulmonary symptoms are also common. However, diagnosis requires ruling out other potential causes. We present a case of a 58-year-old African-American woman with diabetes mellitus who presented with right flank pain and was found to have elevated creatinine (4.4 mg/dL) and severe hypercalcemia (15.3 mg/dL). Imaging revealed extensive lymphadenopathy, leading to suspicion of lymphoma. A comprehensive workup, including lymph node biopsy, ruled out lymphoma, and sarcoidosis was diagnosed. The patient was treated with intravenous (IV) hydration, calcitonin, and pamidronate for hypercalcemia, with subsequent normalization of calcium and improvement in creatinine levels. A lymph node biopsy confirmed granulomatous disease consistent with sarcoidosis. Flow cytometry showed no evidence of lymphoma, and the patient was started on prednisone. Sarcoidosis presents a diagnostic challenge due to its varied presentation and the need for more sensitive and specific diagnostic tests, often leading to under-recognition and misdiagnosis. Studies have found that most patients with pulmonary sarcoidosis also have extrapulmonary involvement, with extrathoracic lymph nodes and skin being the most commonly affected sites. Sarcoidosis-lymphoma syndrome should also be considered, as the incidence of lymphoma is higher in patients with sarcoidosis. However, it can be missed due to similar presentations and a need for more awareness, impacting patient care and prognosis. Our case emphasizes the importance of accurately diagnosing sarcoidosis and ruling out lymphoma and other lymphoproliferative diseases, given their increased incidence in sarcoidosis patients. However, treatment for lymphoma should not be initiated until the diagnosis is confirmed, as sarcoidosis can mimic lymphoma.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.