Evidence map›Paper›PMID 40018496›Full record

ArticleCureus2025

Charting New Territory With a Novel WHO Provisional Category: A Case Study of a Low-Grade Oncocytic Tumor (LOT) in the Kidney.

Jayalakshmi N Alagar, Kassaye Firde, Binyam Fentaw, Samir M Amer, Anjali Seth, Daniela Proca

Abstract readCase Reports
In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jayalakshmi N AlagarPathology and Laboratory Medicine, Temple University Hospital, Philadelphia, USA.
Kassaye FirdePathology and Laboratory Medicine, Temple University Hospital, Philadelphia, USA.
Binyam FentawPathology and Laboratory Medicine, Temple University Hospital, Philadelphia, USA.
Samir M AmerPathology and Laboratory Medicine, Temple University Hospital, Philadelphia, USA.
Anjali SethMolecular Pathology, Temple University Hospital, Philadelphia, USA.
Daniela ProcaPathology, Temple University, Philadephia, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A low-grade oncocytic tumor of the kidney (LOT) is a distinctive entity categorized under the 2022 World Health Organization (WHO) classification as "Other oncocytic tumors of the kidney." It represents a unique subset of oncocytic tumors, distinct from oncocytoma and chromophobe renal cell carcinoma. Characterized by bland oncocytic cells that diffusely express CK7 and lack CD117 expression, LOT typically manifests as a solitary, small lesion with a low stage. Available data suggest that LOT follows an indolent clinical course. Herein, we present a case of LOT in a 64-year-old male with a favorable course at a one-year follow-up. Understanding the clinical, morphological, and immunophenotypic features of LOT is paramount for accurate identification and characterization. This knowledge facilitates more conservative surgical and clinical management, optimizing patient care and outcomes.

Indexed as

chromophobe renal carcinomaimmunohistochemistrylow-grade oncocytic tumors of the kidneyrenalrenal oncocytoma

Identifiers

PMID40018496
PMCPMC11867201

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.