ArticleFrontiers in digital health2025
Evaluating the feasibility of using the Multiphase Optimization Strategy framework to assess implementation strategies for digital mental health applications activations: a proof of concept study.
Article in Frontiers in digital health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Despite the effectiveness and potential of digital mental health interventions (DMHIs) in routine care, their uptake remains low. In Germany, digital mental health applications (DiGA), certified as low-risk medical devices, can be prescribed by healthcare professionals (HCPs) to support the treatment of mental health conditions. The objective of this proof-of-concept study was to evaluate the feasibility of using the Multiphase Optimization Strategy (MOST) framework when assessing implementation strategies. Methods: We tested the feasibility of the MOST by employing a 2 Results: The results primarily demonstrated the feasibility of applying the MOST to a non-randomized setting. Furthermore, analyses indicated significant differences between the groups of HCPs receiving specific implementation strategies [ Discussion and limitations: These findings support the feasibility of using the MOST to evaluate implementation strategies in digital mental health care. It also gives an exploratory example on how to conduct factorial designs with information on implementation strategies. However, limitations such as non-random assignment, underpowered analysis, and varying approaches to HCPs affect the robustness and generalizability of the results. Despite these limitations, the results demonstrate that the MOST is a viable method for assessing implementation strategies, highlighting the importance of planning and optimizing strategies before their implementation. By addressing these limitations, healthcare providers and policymakers can enhance the adoption of digital health innovations, ultimately improving access to mental health care for a broader population.
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