Evidence map›Paper›PMID 40018362›Full record

ArticleFrontiers in neuroscience2025

Comparative analysis of AAV serotypes for transduction of olfactory sensory neurons.

Benjamin D W Belfort, Johnathan D Jia, Alexandra R Garza, Anthony M Insalaco, J P McGinnis, Brandon T Pekarek, Joshua Ortiz-Guzman, Burak Tepe, Hu Chen, aSCENT-PD Investigators and 2 more

Abstract read
In one paragraph

Article in Frontiers in neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Benjamin D W Belfort *Genetics and Genomics Graduate Program, Baylor College of Medicine, Houston, TX, United States.
Johnathan D Jia *Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX, United States.
Alexandra R Garza *Genetics and Genomics Graduate Program, Baylor College of Medicine, Houston, TX, United States.
Anthony M Insalaco *Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, United States.
J P McGinnisJan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX, United States.
Brandon T PekarekGenetics and Genomics Graduate Program, Baylor College of Medicine, Houston, TX, United States.
Joshua Ortiz-GuzmanJan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX, United States.
Burak TepeDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, United States.
Hu ChenJan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX, United States.
aSCENT-PD Investigators
Zhandong LiuJan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX, United States.
Benjamin R ArenkielDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, United States.

Funding

Preclinical and Clincial OutcomesP50HD103555 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI MIRJANA MALETIC-SAVATIC · 2020 to 2026
$9.9M
Steps towards a paternal gene activation therapy for Angelman syndromeU54HD083092 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI NELSON, DAVID LOREN, NEUL, JEFFREY L · 2014 to 2019
$7.8M
R01 Application:Genetically Dissecting Cholinergic Signaling in Body Weight Control.R01DK109934 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI Benjamin R Arenkiel, Qingchun Tong · 2016 to 2026
$5.4M
MAPPING CONNECTIVITY ONTO POSTNATAL-BORN NEURONSR01NS078294 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI ARENKIEL, BENJAMIN R · 2012 to 2023
$3.6M
A CHOLINERGIC NEUROCIRCUIT REGULATES FEEDING BEHAVIORR01DK138518 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI Benjamin R Arenkiel, YONG XU · 2024 to 2026
$1.9M
Uncharted Territory: Mapping and Manipulating Cholinergic Basal Forebrain Activity in a Mouse Model of Alzheimer's DiseaseF30AG076265 · NIA · BAYLOR COLLEGE OF MEDICINE · PI BELFORT, BENJAMIN · 2022 to 2025
$144k
NIA NIH HHS F30 AG076265NICHD NIH HHS P50 HD103555NICHD NIH HHS U54 HD083092NIDDK NIH HHS R01 DK109934NIDDK NIH HHS R01 DK138518NINDS NIH HHS R01 NS078294
6 · The paper itself

Abstract

Olfactory sensory neurons within the nasal epithelium detect volatile odorants and relay odor information to the central nervous system. Unlike other sensory inputs, olfactory sensory neurons interface with the external environment and project their axons directly into the central nervous system. The use of adeno-associated viruses to target these neurons has garnered interest for applications in gene therapy, probing olfactory sensory neuron biology, and modeling disease. To date, there is no consensus on the optimal AAV serotype for efficient and selective transduction of olfactory sensory neurons

Indexed as

AAVgene therapyolfactionolfactory sensory neuronssnRNAseq

Identifiers

PMID40018362
PMCPMC11865030

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.