Evidence map›Paper›PMID 40018355›Full record

ArticleFrontiers in medicine2025

An aerobe exercise intervention for optimizing metabolic, cardiovascular and immune status: protocol of an intervention study with a multi-systemic approach for women with unexplained recurrent pregnancy loss.

Denise Habets, Aysel Gurbanova, Amber Lombardi, Salwan Al-Nasiry, Marc Spaanderman, Renate van der Molen, Lotte Wieten, Tess Meuleman

Abstract read
In one paragraph

Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Denise HabetsDepartment of Transplantation Immunology, Maastricht University Medical Centre, Maastricht, Netherlands.
Aysel GurbanovaDepartment of Laboratory Medicine, Laboratory of Medical Immunology, Radboud University Medical Center, Nijmegen, Netherlands.
Amber LombardiDepartment of Transplantation Immunology, Maastricht University Medical Centre, Maastricht, Netherlands.
Salwan Al-NasiryDepartment of Obstetrics and Gynecology, Maastricht University Medical Centre, Maastricht, Netherlands.
Marc SpaandermanDepartment of Obstetrics and Gynecology, Maastricht University Medical Centre, Maastricht, Netherlands.
Renate van der MolenDepartment of Laboratory Medicine, Laboratory of Medical Immunology, Radboud University Medical Center, Nijmegen, Netherlands.
Lotte WietenDepartment of Transplantation Immunology, Maastricht University Medical Centre, Maastricht, Netherlands.
Tess MeulemanDepartment of Obstetrics and Gynecology, Radboud University Medical Centre, Nijmegen, Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Women confronted with recurrent pregnancy loss (RPL) are often desperately searching for a possible explanation and hoping they will someday fulfill a healthy pregnancy. Unfortunately, in more than 50% of these women no cause for their losses can be identified after clinical investigations and therefore clinicians have no treatment options to help these women. Although adaptations in several systems such as the metabolic, the cardiovascular, and the immune system are highly important to support early pregnancy, especially the contribution of a specific subset of immune cells in the uterus known as CD56

Indexed as

cardiovascular systemexercise interventionimmune systemmetabolic systemrecurrent pregnancy loss

Identifiers

PMID40018355
PMCPMC11866123

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.