Evidence map›Paper›PMID 40018344›Full record

ArticleFrontiers in medicine2025

A prolonged activated partial thromboplastin time indicates poor short-term prognosis in patients with hepatic encephalopathy: insights from the MIMIC database.

Liping Zhan, Yuping Yang, Biao Nie, Yanqi Kou, Shenshen Du, Yuan Tian, Yujie Huang, Ruyin Ye, Zhe Huang, Botao Luo and 2 more

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In one paragraph

Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Liping Zhan *Department of Gastroenterology, Affiliated Hospital of Guangdong Medical University, Guangdong Medical University, Zhanjiang, China.
Yuping Yang *Department of Gastroenterology, Affiliated Hospital of Guangdong Medical University, Guangdong Medical University, Zhanjiang, China.
Biao Nie *Department of Gastroenterology, Affiliated Hospital of Guangdong Medical University, Guangdong Medical University, Zhanjiang, China.
Yanqi Kou *Department of Gastroenterology, Affiliated Hospital of Guangdong Medical University, Guangdong Medical University, Zhanjiang, China.
Shenshen DuDepartment of Gastroenterology, Affiliated Hospital of Guangdong Medical University, Guangdong Medical University, Zhanjiang, China.
Yuan TianDepartment of Pathology, Guangdong Medical University, Zhanjiang, China.
Yujie HuangDepartment of Gastroenterology, Affiliated Hospital of Guangdong Medical University, Guangdong Medical University, Zhanjiang, China.
Ruyin YeDepartment of Gastroenterology, Affiliated Hospital of Guangdong Medical University, Guangdong Medical University, Zhanjiang, China.
Zhe HuangDepartment of Colorectal Surgery, Affiliated Hospital of Guangdong Medical University, Guangdong Medical University, Zhanjiang, China.
Botao LuoDepartment of Pathology, Guangdong Medical University, Zhanjiang, China.
Lei GeDepartment of Gastrointestinal Surgery, Affiliated Hospital of Guangdong Medical University, Guangdong Medical University, Zhanjiang, China.
Shicai YeDepartment of Gastroenterology, Affiliated Hospital of Guangdong Medical University, Guangdong Medical University, Zhanjiang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: This study investigates serum markers for short-term prognosis in hepatic encephalopathy patients. Background: Patients with hepatic encephalopathy face elevated mortality rates and bleak prognoses. However, effective prognostic models or indicators are lacking. This study aims to explore serum markers for predicting short-term prognosis in these patients. Methods: We conducted a retrospective analysis of 552 patients with hepatic encephalopathy, categorizing 429 individuals meeting exclusion criteria into normal and high activated partial thromboplastin time (APTT) groups. We assessed 12-day and 25-day survival rates using Kaplan-Meier analysis and Cox regression models to examine associations between groups and outcomes. Results: Upon comparing baseline characteristics, the high APTT group exhibited significant disparities in acute kidney injury, sepsis, coagulation disorders, and ascites ( Conclusion: A prolonged APTT suggests a poorer short-term prognosis in patients with hepatic encephalopathy.

Indexed as

activated partial thromboplastin time (APTT)databasehepatic encephalopathyprognosisrisk factors

Identifiers

PMID40018344
PMCPMC11865095

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.