Evidence map›Paper›PMID 40018087›Full record

ArticleObesity science & practice2025

Pancreatic β-cell Function is Higher in Morning Versus Intermediate Chronotypes With Obesity.

Steven K Malin, Mary-Margaret E Remchak, Emily M Heiston, Chiara Fabris, Ankit M Shah

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Obesity science & practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It reports registered trial NCT03355469. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03355469 phase2 / phase3completed

Exercise Dose and Metformin for Vascular Health in Adults With Metabolic Syndrome

Ran2017Enrolled91Registered outcomes6Posted comparisons36ConditionsMetabolic SyndromeArmsHigh intensity exercise, Low intensity exercise, Metformin, Placebo
PMID 26583801PMID 11300445PMID 22040838PMID 16115299PMID 23505172PMID 20057377PMID 12379578PMID 12677025PMID 12767663PMID 16644702PMID 16682488PMID 17785362other papers from this trial
Open the trial in the graph
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Sleep and circadian effects on the incretin system.Current sleep medicine reports · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Steven K MalinDepartment of Kinesiology & Health Rutgers University New Brunswick New Jersey USA.ORCID https://orcid.org/0000-0002-7360-6711
Mary-Margaret E RemchakDepartment of Kinesiology & Health Rutgers University New Brunswick New Jersey USA.
Emily M HeistonDepartment of Kinesiology & Health Rutgers University New Brunswick New Jersey USA.
Chiara FabrisCenter for Diabetes Technology School of Medicine University of Virginia Charlottesville Virginia USA.
Ankit M ShahDivision of Endocrinology, Metabolism & Nutrition Rutgers University New Brunswick New Jersey USA.

Funding

Exercise Dose and Metformin for Vascular Health in Adults with Metabolic SyndromeR01HL130296 · NHLBI · UNIVERSITY OF VIRGINIA · PI MALIN, STEVEN K · 2017 to 2021
$3.7M
NHLBI NIH HHS R01 HL130296
6 · The paper itself

Abstract

Objectives: People with later chronotypes are at greater T2D risk, yet it is unknown if β-cell function differs among chronotypes. Thus we, assessed β-cell function in morning (MORN) and intermediate (INT) chronotypes with obesity. Methods: Adults ( Results: Age, body composition and VO Conclusions: β-cell function was higher in MORN versus INT chronotypes. Further work is warranted to discern how chronotype impacts insulin secretion. Trial Registration: NCT03355469.

Indexed as

glycemic controlincretinsinsulin resistanceinsulin secretiontype 2 diabetes

Identifiers

PMID40018087
PMCPMC11864105

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.