Evidence map›Paper›PMID 40018044›Full record

ArticleFrontiers in immunology2025

Monocyte-derived Langerhans cells express Delta-like 4 induced by peptidoglycan and interleukin-4 mediated suppression.

Rei Ono, Kohei Maeda, Toshihiro Tanioka, Takeo Isozaki

Abstract read
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Rei OnoDepartment of Pathogenesis and Translational Medicine, Showa University Graduate School of Pharmacy, Tokyo, Japan.
Kohei MaedaDepartment of Pathogenesis and Translational Medicine, Showa University Graduate School of Pharmacy, Tokyo, Japan.
Toshihiro TaniokaDepartment of Pathogenesis and Translational Medicine, Showa University Graduate School of Pharmacy, Tokyo, Japan.
Takeo IsozakiDepartment of Pathogenesis and Translational Medicine, Showa University Graduate School of Pharmacy, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

T cells contribute to immunotherapy and autoimmune pathogenesis and Langerhans cells (LCs) have a substantial ability to activate T cells.

Indexed as

Adaptor Proteins, Signal TransducingCalcium-Binding ProteinsInterleukin-4Langerhans CellsMonocytesPeptidoglycanCells, CulturedDendritic CellsHumansLymphocyte ActivationT-LymphocytesTransforming Growth Factor beta1Adaptor Proteins, Signal TransducingCalcium-Binding ProteinsDLL4 protein, humanIL4 protein, humanInterleukin-4PeptidoglycanTransforming Growth Factor beta1autoimmune diseasesDelta-like 1Delta-like 4Langerhans cellsmonocytepsoriasisT celltoll-like receptor

Identifiers

PMID40018044
PMCPMC11865044

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.