Evidence map›Paper›PMID 40017804›Full record

ArticleJournal of immunology research2025

Nucleated Red Blood Cells Secrete Haptoglobin to Induce Immunosuppressive Function in Monocytes.

Shusuke Takeuchi, Satoshi Fujiyama, Motomichi Nagafuji, Miyuki Mayumi, Makoto Saito, Mana Obata-Yasuoka, Hiromi Hamada, Yayoi Miyazono, Hidetoshi Takada

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of immunology research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Shusuke TakeuchiDepartment of Pediatrics, University of Tsukuba Hospital, Tsukuba, Ibaraki, Japan.ORCID https://orcid.org/0000-0003-4341-6973
Satoshi FujiyamaDepartment of Pediatrics, University of Tsukuba Hospital, Tsukuba, Ibaraki, Japan.ORCID https://orcid.org/0000-0003-0433-6364
Motomichi NagafujiDepartment of Pediatrics, University of Tsukuba Hospital, Tsukuba, Ibaraki, Japan.ORCID https://orcid.org/0000-0001-5063-0578
Miyuki MayumiDepartment of Obstetrics and Gynecology, Institute of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.ORCID https://orcid.org/0000-0002-4057-264X
Makoto SaitoDepartment of Pediatrics, University of Tsukuba Hospital, Tsukuba, Ibaraki, Japan.ORCID https://orcid.org/0000-0002-0778-3410
Mana Obata-YasuokaDepartment of Obstetrics and Gynecology, Institute of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.ORCID https://orcid.org/0000-0002-7663-1808
Hiromi HamadaDepartment of Obstetrics and Gynecology, Institute of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.ORCID https://orcid.org/0000-0002-0560-7034
Yayoi MiyazonoDepartment of Pediatrics, University of Tsukuba Hospital, Tsukuba, Ibaraki, Japan.ORCID https://orcid.org/0000-0001-6195-0737
Hidetoshi TakadaDepartment of Pediatrics, University of Tsukuba Hospital, Tsukuba, Ibaraki, Japan.ORCID https://orcid.org/0000-0002-0741-5060

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nucleated red blood cells (NRBCs) are precursors of red blood cells (RBCs), but also possess variety of immunomodulatory effects. However, among the three types of NRBCs, the immunological effects of human CD45- NRBCs remain largely unknown. We have previously shown that cord blood-derived CD45- NRBCs and adult peripheral blood-derived monocytes cocultured in a lipopolysaccharide (LPS)-stimulated indirect coculture system that avoided cell-to-cell contact, increase IL-10 and decrease TNF-

Indexed as

ErythroblastsErythrocytesHaptoglobinsImmune ToleranceMonocytesAdultAntigens, CDAntigens, Differentiation, MyelomonocyticCD163 AntigenCells, CulturedCoculture TechniquesHeme Oxygenase-1HumansInterleukin-10Receptors, Cell SurfaceAntigens, CDAntigens, Differentiation, MyelomonocyticCD163 AntigenHaptoglobinsHeme Oxygenase-1Interleukin-10Receptors, Cell SurfacehaptoglobinIL-10monocytenucleated red blood cellumbilical cord blood

Identifiers

PMID40017804
PMCPMC11867727

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.