ArticleJACS Au2025
N-Heterocyclic-Carbene-Catalyzed Imine Umpolung for the Cross-Coupling of Quinoxalin-2-ones with Isatins.
Article in JACS Au, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The N-heterocyclic carbene (NHC)-catalyzed umpolung of aldimines using quinoxalin-2-ones for intermolecular reactions is demonstrated. Specifically, NHC-catalyzed cross-coupling of quinoxalin-2-ones with isatins proceeds via the generation of aza-Breslow intermediates by the addition of carbene to the C=N moiety of quinoxalinones followed by interception with isatins to afford diverse oxindoles in moderate to good yields and good functional group compatibility. Moreover, detailed mechanistic studies involving the isolation and characterization of the imidoyl azoliums (oxidized form of the aza-Breslow intermediates) are provided. Considering the significance of scaffolds bearing both quinoxalin-2-one and oxindole moieties in medicine and natural products, the synthesized molecules employing the NHC-catalyzed imine umpolung strategy are likely to find promising applications.
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