Evidence map›Paper›PMID 40017765›Full record

ArticleJACS Au2025

Metabolic PCTA-Based Shift Reagents for the Detection of Extracellular Lactate Using CEST MRI.

Remy Chiaffarelli, Pedro F Cruz, Jonathan Cotton, Tjark Kelm, Slade Lee, Mohammad Ghaderian, Max Zimmermann, Carlos F G C Geraldes, Paul Jurek, André F Martins

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACS Au, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Remy ChiaffarelliWerner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, University Hospital Tübingen, Tübingen 72076, Germany.
Pedro F CruzCoimbra Chemistry Center-Institute of Molecular Sciences (CQC-IMS), Faculty of Science and Technology, University of Coimbra, Coimbra 3004-535, Portugal.
Jonathan CottonWerner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, University Hospital Tübingen, Tübingen 72076, Germany.
Tjark KelmWerner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, University Hospital Tübingen, Tübingen 72076, Germany.
Slade LeeMacrocyclics, Inc., Plano, Texas 75074, United States.
Mohammad GhaderianWerner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, University Hospital Tübingen, Tübingen 72076, Germany.
Max ZimmermannWerner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, University Hospital Tübingen, Tübingen 72076, Germany.
Carlos F G C GeraldesCoimbra Chemistry Center-Institute of Molecular Sciences (CQC-IMS), Faculty of Science and Technology, University of Coimbra, Coimbra 3004-535, Portugal.
Paul JurekMacrocyclics, Inc., Plano, Texas 75074, United States.ORCID https://orcid.org/0000-0001-9390-046X
André F MartinsWerner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, University Hospital Tübingen, Tübingen 72076, Germany.ORCID https://orcid.org/0000-0002-0171-0261

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lactate is a key metabolic driver in oncology and immunology. Even in the presence of physiological oxygen levels, most cancer cells upregulate anaerobic glycolysis, resulting in abnormal lactate production and accumulation in the tumor microenvironment. The development of more effective, sensitive, and safe probes for detecting extracellular lactate holds the potential to significantly impact cancer metabolic profiling and staging significantly. Macrocyclic-based PARACEST agents have been reported to act as shift reagents (SRs) and detect extracellular lactate via chemical exchange saturation transfer (CEST) MRI. Here, we introduce a new family of SRs based on the PCTA ligand, an inherently stable and kinetically inert group of molecules with the potential for (pre)clinical translation. We observed that Yb-PCTA and Eu-PCTA can significantly shift lactate -OH signals in the CEST spectra.

Identifiers

PMID40017765
PMCPMC11862947

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.