ArticleJACS Au2025
Unveiling the Role of Alkyl Chain in Boosting Antibacterial Selectivity and Cell Biocompatibility.
Article in JACS Au, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Thiophene-Engineered Lipid II Recognition Enables Potent Membranolytic Eradication of MRSA.Angewandte Chemie (International ed. in English) · 2026Article
- Advances in BODIPY Derivatives for Antibacterial Phototherapy.Angewandte Chemie (International ed. in English) · 2026Review
- Charge-Competition AIEgens Induce Mitochondrial Dysfunction for Selective Eradication ofJournal of microbiology and biotechnology · 2026Article
- Engineered BioAIE photosensitizer from natural cryptolepine: Amplifying type I/II ROS for photodynamic eradication of bacteria.Materials today. Bio · 2026Article
- Synthesis and Characterization of Biomimetic Thermoplastic Polyurethanes and Nanocomposites with l-Lysine Diisocyanate.Biomacromolecules · 2026Article
- An innovative strategy to treat pathogenic biofilm-associated infectionsRSC medicinal chemistry · 2025Article
- Strategies and applications of antibacterial surface-modified biomaterials.Bioactive materials · 2025Review
- In Situ Polymerization of Long Alkyl Chain Functional Groups Enhances the Oil-Water Separation Performance of Porous Organic Polymers.Molecules (Basel, Switzerland) · 2025Article
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cationic amphiphiles have been demonstrated to be superior targeted antibacterial agents whose antibacterial activity exhibits a close relationship with their alkyl chain substituents. However, a systematic and deep investigation of the structure-property relationship is still pending. Meanwhile, cationic amphiphiles have a risk of accumulating in living mammalian cells, which poses a great threat to biosafety and clinical applications. In this study, a series of cationic amphiphilic aggregation-induced emission luminogens (AIEgens) with different alkyl chains (TPD-4, TPD-6, and TPD-12) have been developed with selective and variable antibacterial activity against Gram-positive bacteria depending on the alkyl chain length. Among them, TPD-6 with the intermediate alkyl chain length exhibited superior Gram-positive antibacterial performance. In addition, these cationic amphiphilic AIEgens had negligible invasiveness to mammalian cells. Molecular dynamics simulations revealed that the binding and deforming capabilities of the cationic amphiphilic AIEgens to the phospholipid bilayer of bacteria are responsible for their antibacterial activity. In vivo experiments indicated that TPD-6 also exhibited significant antibacterial and wound-healing abilities against Gram-positive bacteria.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.