Evidence map›Paper›PMID 40017760›Full record

ArticleJACS Au2025

Introducing Regioselective Disulfide Linkages in Peptides under Pseudodilute Conditions by Harnessing Bro̷nsted Acid-Activated

Nitesh Mani Tripathi, Basab Kanti Das, Arnab Chowdhury, Vinod Gour, Anupam Bandyopadhyay

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACS Au, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Nitesh Mani TripathiBiomimetic Peptide Engineering Laboratory, Department of Chemistry, Indian Institute of Technology, Ropar, Rupnagar, Punjab140001, India.ORCID https://orcid.org/0000-0002-8235-8297
Basab Kanti DasBiomimetic Peptide Engineering Laboratory, Department of Chemistry, Indian Institute of Technology, Ropar, Rupnagar, Punjab140001, India.
Arnab ChowdhuryBiomimetic Peptide Engineering Laboratory, Department of Chemistry, Indian Institute of Technology, Ropar, Rupnagar, Punjab140001, India.ORCID https://orcid.org/0000-0003-3342-2237
Vinod GourBiomimetic Peptide Engineering Laboratory, Department of Chemistry, Indian Institute of Technology, Ropar, Rupnagar, Punjab140001, India.
Anupam BandyopadhyayBiomimetic Peptide Engineering Laboratory, Department of Chemistry, Indian Institute of Technology, Ropar, Rupnagar, Punjab140001, India.ORCID https://orcid.org/0000-0002-3221-0315

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Methods that assemble multiple peptide disulfide bonds in the solid phase (pseudodilute conditions) are in high demand for synthesizing disulfide-rich peptides. Yet, the existing repertoire of disulfide-forming orthogonal chemistries in the solid phase is often hindered by additional steps for protecting group removals as well as the absolute necessity of rare, customized orthogonal cysteine (Cys) building blocks. We now describe a conceptually new while operationally simple on-resin method for disulfide assembly with widely accessible Cys protecting groups (Trt, Acm, and

Identifiers

PMID40017760
PMCPMC11862937

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.