Evidence map›Paper›PMID 40017731›Full record

ArticleComputational and structural biotechnology journal2025

Disrupting the network of co-evolving amino terminal domain residues relieves mitochondrial calcium uptake inhibition by MCUb.

Danielle M Colussi, Ryan Grainger, Megan Noble, Taylor Lake, Murray Junop, Peter B Stathopulos

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Computational and structural biotechnology journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Danielle M ColussiDepartment of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, N6A5C1, Canada.
Ryan GraingerDepartment of Biochemistry, Schulich School of Medicine and Dentistry, University of Western Ontario, N6A5C1, Canada.
Megan NobleDepartment of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, N6A5C1, Canada.
Taylor LakeDepartment of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, N6A5C1, Canada.
Murray JunopDepartment of Biochemistry, Schulich School of Medicine and Dentistry, University of Western Ontario, N6A5C1, Canada.
Peter B StathopulosDepartment of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, N6A5C1, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The regulatory mechanisms of the mitochondrial calcium uniporter complex (mtCU), the predominant channel mediating calcium (Ca

Indexed as

Amino-terminal domainDivalent cation bindingFeedback regulationMCU dominant-negative beta (MCUb)Mitochondrial Ca2+ uptakeMitochondrial calcium uniporter (MCU)Molecular dynamicsPySCA of residue co-evolutionSolution NMRX-ray crystallography

Identifiers

PMID40017731
PMCPMC11867204

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.