ReviewJournal of oral & maxillofacial research
A Comprehensive Analysis of the Association between Thyroid Dysfunctions and Periodontal Health: Systematic Review.
Review in Journal of oral & maxillofacial research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Periodontal disease in patients with thyroid disorders: a systematic review and meta-analysis.Odontology · 2026Review
- Periodontal disease and endocrine imbalance: a molecular pathways perspective.Frontiers in dental medicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives: The purpose of this systematic literature review was to establish a correlation between thyroid dysfunctions and periodontium health. Material and Methods: The systematic review was conducted according to PRISMA statement. An electronic search was performed using MEDLINE (PubMed) and Google Scholar databases using a combination of keywords "hypothyroidism", "hypothyroidism", "thyroid", "thyroid dysfunction" and "periodontitis". The research covered the period from January 1, 2019 and July 1, 2024, included studies written in English, conducted in humans. Results: The results showed that hyperthyroidism can be associated with a higher prevalence of periodontitis due to decreased oral microbiome diversity, serum thyroid-stimulating hormone levels, increased periodontal pocket depth, clinical attachment loss and interleukin-6. Hyperparathyroidism after parathyroidectomy may lead to a slightly higher risk of tooth extraction in the first two years afterward because decreasing lamina dura, increasing periodontal ligament width. And hypothyroidism negatively affects the homeostasis of calcium and phosphorus in the oral fluid and can change the composition of bone minerals. Conclusions: Hyperthyroidism increases the risk of periodontitis by promoting deeper periodontal pockets, reducing oral microbiome diversity, altering alveolar bone structure and elevating inflammatory markers like interleukin-6, which are linked to disease progression. Hypothyroidism worsens periodontal disease by disrupting calcium-phosphorus balance and causing alveolar bone changes, especially in young individuals. Both conditions affect periodontal homeostasis, emphasizing the bidirectional relationship between endocrine and periodontal health. Dentists should monitor thyroid dysfunction, as managing thyroid levels may improve periodontal treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.