ArticleRSC advances2025
Doxorubicin-loaded pH-responsive porphyrin-derived carbon dots as a promising biocompatible drug delivery system for effective chemotherapy of breast cancer.
Article in RSC advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The trial behind it
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Who cites it
6 citing papers in PubMed.
- Encapsulation of carbon dots in medicinal chemistry: a comprehensive review of recent advances and applications.RSC advances · 2026Review
- Nanostructured Lipid Carriers Containing Acridine Derivatives in the Application of Sonodynamic Therapy for the Treatment of Breast Cancer.ACS omega · 2026Article
- Quantum Dots: Catalysts for a New Era of Precision Medicine and Biomedical Innovation.Journal of fluorescence · 2026Review
- Multifunctional N-substituted 2-pyridylbenzothiazole derivatives: singlet oxygen generation, protein binding, and photoactivated anticancer and antibacterial activities.RSC advances · 2025Article
- pH-responsive doxorubicin-loadedRSC advances · 2025Article
- Theoretical study of 2D cancer drug nanocarriers based on calcium chloride.Journal of molecular modeling · 2025Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Doxorubicin (DOX), a widely used chemotherapy drug for breast cancer, suffers from limitations such as non-specific toxicity and drug resistance. To address these challenges, we developed a novel drug delivery system (DDS) using porphyrin-derived carbon dots (CDs) as carriers for DOX. Porphyrin-based CDs were synthesized solvothermally from tetrakis(4-carboxyphenyl) porphyrin (TCPP) and urea. DOX was non-covalently loaded onto the CDs to form the DOX@CDs nanocomposite. The resulting CDs exhibited desirable properties like excellent water solubility, stability, and biocompatibility. Moreover, the DOX@CDs complex showed a high drug loading efficiency of 93% and a pH-responsive release profile, with enhanced release at acidic tumor microenvironments. The DOX@CDs nanocomposite demonstrated significantly improved cytotoxicity against human breast cancer MCF-7 and MDA-MB-231 cell lines (at IC
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Registered trials
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