Evidence map›Paper›PMID 40017617›Full record

ArticleFrontiers in oral health2025

Yeast cell wall derivatives as a potential strategy for modulating oral microbiota and dental plaque biofilm.

Torsten P M Scheithauer, Isabela M Fernandes de Oliveira, Michel Ossendrijver, Elodie Dehay, Michelle van der Wurff, Hakim Rahaoui, Nathalie Ballet, Bart J F Keijser

Abstract read
In one paragraph

Article in Frontiers in oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Torsten P M ScheithauerDepartment of Microbiology & Systems Biology, TNO, Leiden, Netherlands.
Isabela M Fernandes de OliveiraDepartment of Microbiology & Systems Biology, TNO, Leiden, Netherlands.
Michel OssendrijverDepartment of Microbiology & Systems Biology, TNO, Leiden, Netherlands.
Elodie DehayScientific Affairs, Gnosis by Lesaffre, Marcq-en-Baroeul, France.
Michelle van der WurffDepartment of Microbiology & Systems Biology, TNO, Leiden, Netherlands.
Hakim RahaouiDepartment of Microbiology & Systems Biology, TNO, Leiden, Netherlands.
Nathalie BalletDiscovery & Front-End Innovation, Lesaffre Institute of Science & Technology, Lesaffre International, Marcq-en-Baroeul, France.
Bart J F KeijserDepartment of Microbiology & Systems Biology, TNO, Leiden, Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Derivatives from Methods: An Results: Yeast extracts had only minor effects on oral biofilm formation. In contrast, yeast cell wall derivatives, which are rich in polysaccharides such as beta-glucans and mannans, significantly reduced the density of the oral biofilms Conclusion: This study has demonstrated the potential of yeast cell wall derivatives to positively impact oral health by significantly reducing biofilm density, modulating the oral microbial composition, and decreasing the production of short-chain fatty acids. The observed effects highlight the promising applications of these yeast-based compounds as an approach to managing oral diseases. Further research is needed to fully elucidate the mechanisms of action and explore the clinical potential of yeast cell wall derivatives in promoting and maintaining oral health.

Indexed as

biofilmoral healthoral microbiotaperiodontitispostbioticyeast

Identifiers

PMID40017617
PMCPMC11865069

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.