Evidence map›Paper›PMID 40017600›Full record

ArticleFrontiers in pharmacology2025

UPLC-MS/MS method for simultaneous determination of pyrantel, praziquantel, febantel, fenbendazole and oxfendazole in dog plasma and its application to a bioequivalence study.

Fengyichi Zhang, Fanxi Guo, Xinyu Zhao, Chongyang Li, Junli Wang, Mengyun Wang, Ruixia Ma, Baochang Chen, Qiangqiang Miao, Yimeng Wang and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Fengyichi Zhang *Laboratory of Veterinary Pharmacology and Toxicology, Department of Basic Veterinary Medicine, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China.
Fanxi Guo *Laboratory of Veterinary Pharmacology and Toxicology, Department of Basic Veterinary Medicine, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China.
Xinyu ZhaoLaboratory of Veterinary Pharmacology and Toxicology, Department of Basic Veterinary Medicine, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China.
Chongyang LiLaboratory of Veterinary Pharmacology and Toxicology, Department of Basic Veterinary Medicine, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China.
Junli WangLaboratory of Veterinary Pharmacology and Toxicology, Department of Basic Veterinary Medicine, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China.
Mengyun WangLaboratory of Veterinary Pharmacology and Toxicology, Department of Basic Veterinary Medicine, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China.
Ruixia MaLaboratory of Veterinary Pharmacology and Toxicology, Department of Basic Veterinary Medicine, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China.
Baochang ChenLaboratory of Veterinary Pharmacology and Toxicology, Department of Basic Veterinary Medicine, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China.
Qiangqiang MiaoLaboratory of Veterinary Pharmacology and Toxicology, Department of Basic Veterinary Medicine, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China.
Yimeng WangLaboratory of Veterinary Pharmacology and Toxicology, Department of Basic Veterinary Medicine, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China.
Zihan WangLaboratory of Veterinary Pharmacology and Toxicology, Department of Basic Veterinary Medicine, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China.
Di CaoLaboratory of Veterinary Pharmacology and Toxicology, Department of Basic Veterinary Medicine, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China.
Zugong YuLaboratory of Veterinary Pharmacology and Toxicology, Department of Basic Veterinary Medicine, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A rapid, sensitive and reliable ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) was developed and validated for the simultaneous quantitation of pyrantel (PYR), praziquantel (PRA), febantel (FBT) and its active metabolites, fenbendazole (FEN) and oxfendazole (OXF) in dog plasma. Fenbendazole-D3 (FEN-D3) was used as an internal standard (IS). The analytes and IS were prepared using simple protein precipitation (PP) combined with liquid-liquid extraction (LLE). Chromatographic analysis was performed on UPLC BEH C

Indexed as

bioequivalencedog plasma concentrationfebantelfenbendazoleoxfendazolepraziquantelpyrantelUPLC-MS/MS

Identifiers

PMID40017600
PMCPMC11864945

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.