Evidence map›Paper›PMID 40017585›Full record

ArticlePathogens & immunity2024

A Refined Human Linear B Cell Epitope Map of Outer Surface Protein C (OspC) From the Lyme Disease Spirochete,

Grace Freeman-Gallant, Kathleen McCarthy, Jennifer Yates, Karen Kulas, Michael J Rudolph, David J Vance, Nicholas J Mantis

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pathogens & immunity, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Grace Freeman-GallantDivision of Infectious Diseases, Wadsworth Center, New York State Department of Health, Albany, New York.
Kathleen McCarthyDepartment of Biomedical Sciences, University at Albany, Albany, New York.
Jennifer YatesDivision of Infectious Diseases, Wadsworth Center, New York State Department of Health, Albany, New York.
Karen KulasDivision of Infectious Diseases, Wadsworth Center, New York State Department of Health, Albany, New York.
Michael J RudolphNew York Structural Biology Center, New York, New York.
David J VanceDivision of Infectious Diseases, Wadsworth Center, New York State Department of Health, Albany, New York.
Nicholas J MantisDivision of Infectious Diseases, Wadsworth Center, New York State Department of Health, Albany, New York.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: A detailed understanding of the human antibody response to outer surface protein C (OspC) of Methods: In this report, 13 peptides encompassing 8 reported OspC linear B-cell epitopes from OspC types A, B, and K, including the largely conserved C-terminus (residues 193-210), were evaluated by multiplex immunoassay (MIA) for IgG reactivity with ~700 human serum samples confirmed positive in a 2-tiered Lyme disease diagnostic assay (Bb Results: Serum IgG from Bb Conclusions: The asynchronous and potentially short-lived serologic response to OspC-derived peptides reveals the complexity of B-cell responses to

Indexed as

antibodyBorrelia burgdorferiBorreliellaepitopehumanLyme diseasepeptidesvaccine

Identifiers

PMID40017585
PMCPMC11867186

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.