Evidence map›Paper›PMID 40017510›Full record

ReviewDEN open2025

Endoscopic risk factors to inform early detection of gastric cancer after

Masaaki Kodama, Osamu Handa, Mitsushige Sugimoto, Takahiro Kotachi, Masaaki Kobayashi, Susumu Take, Shu Hoteya, Katsuhiro Mabe, Takahisa Murao, Ken Namikawa and 3 more

Abstract readReview
In one paragraph

Review in DEN open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Masaaki KodamaDepartment of Advanced Medical Sciences Faculty of Medicine Oita University Oita Japan.ORCID https://orcid.org/0000-0003-0131-9470
Osamu HandaDepartment of Gastroenterology and Hepatology Kawasaki Medical School Okayama Japan.
Mitsushige SugimotoDivision of Genome-Wide Infectious Diseases Research Center for GLOBAL and LOCAL Infectious Diseases Oita University Oita Japan.ORCID https://orcid.org/0000-0002-9194-7392
Takahiro KotachiDepartment of Gastroenterology Hiroshima University Hospital Hiroshima Japan.
Masaaki KobayashiDivision of Gastroenterology, Niigata Cancer Center Hospital Niigata Japan.ORCID https://orcid.org/0000-0003-2766-642X
Susumu TakeDepartment of Gastrointestinal Endoscopy Nippon Kokan Fukuyama Hospital Okayama Japan.
Shu HoteyaDepartment of Gastroenterology Toranomon Hospital Tokyo Japan.
Katsuhiro MabeMabe Goryokaku Gastrointestinal Endoscopy Clinic Hokkaido Japan.
Takahisa MuraoDepartment of Health Care Medicine Kawasaki Medical School General Medical Center Okayama Japan.
Ken NamikawaDepartment of Gastroenterology Cancer Institute Hospital, Japanese Foundation for Cancer Research Tokyo Japan.
Takashi KawaiDepartment of Gastroenterological Endoscopy Tokyo Medical University Hospital Tokyo Japan.
Kazunari MurakamiDepartment of Gastroenterology Faculty of Medicine Oita University Oita Japan.
Research committee for the Establishment of Risk Evaluation of Gastric Cancer after H. pylori Eradication in Endoscopic Findings, The Japanese Society for Helicobacter Research, Japan

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Methods: Medline and PubMed were searched for randomized controlled trials, cohort studies, and case-control studies published in the English-language medical literature between January 1997 and July 2023. The included articles assessed the correlation between post-eradication GC and pre- and post-eradication endoscopic findings, and associated post-eradication GC with gastric atrophy, intestinal metaplasia (IM), map-like redness, and xanthoma. Results: A total of 963 articles were retrieved. In these articles, 66 papers were finally included, comprising randomized controlled trials, cohort studies, and case-control studies. The included articles addressed gastric atrophy (16 studies), IM (eight studies), map-like redness (six studies), and xanthoma (two studies). Risk ratio (RR) of incident post-eradication GC was 3.40 (95%confidence interval [95%CI]: 1.98-5.84; Conclusions: Endoscopic atrophy, IM, and xanthoma observed at pre- and post-eradication time points and post-eradication map-like redness were suggested as endoscopic risk factors for post-eradication GC. Further studies are needed to clarify the risk of post-eradication GC based on these risk factors.

Indexed as

atrophic gastritiseradicationgastric cancerHelicobacter pyloriintestinal metaplasia

Identifiers

PMID40017510
PMCPMC11865013

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.