Evidence map›Paper›PMID 40017464›Full record

ReviewNeurophotonics2025

Ultrafast optical imaging techniques for exploring rapid neuronal dynamics.

Tien Nhat Nguyen, Reham A Shalaby, Eunbin Lee, Sang Seong Kim, Young Ro Kim, Seonghoon Kim, Hyunsoo Shawn Je, Hyuk-Sang Kwon, Euiheon Chung

Abstract readReview
In one paragraph

Review in Neurophotonics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Dual-Channel Event Microscopy for Ultrafast Biological Imaging.bioRxiv : the preprint server for biology · 2025
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Tien Nhat NguyenGwangju Institute of Science and Technology, Department of Biomedical Science and Engineering, Gwangju, Republic of Korea.
Reham A ShalabyGwangju Institute of Science and Technology, Department of Biomedical Science and Engineering, Gwangju, Republic of Korea.ORCID https://orcid.org/0009-0008-2784-6758
Eunbin LeeGwangju Institute of Science and Technology, Department of Biomedical Science and Engineering, Gwangju, Republic of Korea.
Sang Seong KimGwangju Institute of Science and Technology, Department of Biomedical Science and Engineering, Gwangju, Republic of Korea.
Young Ro KimMassachusetts General Hospital, Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, Massachusetts United States.
Seonghoon KimTsinghua University, Institute for Brain and Cognitive Sciences, Beijing, China.ORCID https://orcid.org/0000-0002-1145-0336
Hyunsoo Shawn JeDuke-NUS Medical School, Program in Neuroscience and Behavioral Disorders, Singapore.
Hyuk-Sang KwonGwangju Institute of Science and Technology, Department of Biomedical Science and Engineering, Gwangju, Republic of Korea.
Euiheon ChungGwangju Institute of Science and Technology, Department of Biomedical Science and Engineering, Gwangju, Republic of Korea.ORCID https://orcid.org/0000-0002-3326-6927

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Optical neuroimaging has significantly advanced our understanding of brain function, particularly through techniques such as two-photon microscopy, which captures three-dimensional brain structures with sub-cellular resolution. However, traditional methods struggle to record fast, complex neuronal interactions in real time, which are crucial for understanding brain networks and developing treatments for neurological diseases such as Alzheimer's, Parkinson's, and chronic pain. Recent advancements in ultrafast imaging technologies, including kilohertz two-photon microscopy, light field microscopy, and event-based imaging, are pushing the boundaries of temporal resolution in neuroimaging. These techniques enable the capture of rapid neural events with unprecedented speed and detail. This review examines the principles, applications, and limitations of these technologies, highlighting their potential to revolutionize neuroimaging and improve the diagnose and treatment of neurological disorders. Despite challenges such as photodamage risks and spatial resolution trade-offs, integrating these approaches promises to enhance our understanding of brain function and drive future breakthroughs in neuroscience and medicine. Continued interdisciplinary collaboration is essential to fully leverage these innovations for advancements in both basic and clinical neuroscience.

Indexed as

event-based imagingkilohertz two-photon microscopylight field microscopyneuroimagingultrafast optical imagingvoltage imaging

Identifiers

PMID40017464
PMCPMC11867703

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.