Evidence map›Paper›PMID 40017230›Full record

ArticleVascular and endovascular surgery2025

Asymptomatic Carotid Stenosis is Associated With Mobility Dysfunction: Results From the InChianti Study.

Sarasijhaa K Desikan, James Borrelli, Vicki L Gray, Aman A Kankaria, Michael Terrin, Brajesh K Lal

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Vascular and endovascular surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sarasijhaa K DesikanDivision of Vascular Surgery, University of Maryland School of Medicine, Baltimore, MD, USA.
James BorrelliDepartment of Physical Therapy and Rehabilitation Science, University of Maryland, Baltimore, MD, USA.
Vicki L GrayDepartment of Physical Therapy and Rehabilitation Science, University of Maryland, Baltimore, MD, USA.
Aman A KankariaDivision of Vascular Surgery, University of Maryland School of Medicine, Baltimore, MD, USA.ORCID 0009-0007-5377-9619
Michael TerrinDepartment of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD, USA.
Brajesh K LalDivision of Vascular Surgery, University of Maryland School of Medicine, Baltimore, MD, USA.

Funding

CREST-2 Clinical Coordinating CenterU01NS080168 · NINDS · MAYO CLINIC JACKSONVILLE · PI Thomas G Brott, JAMES F MESCHIA · 2014 to 2026
$56.3M
University of Maryland Claude D. Pepper Older Americans Independence Center (UM-OAIC)P30AG028747 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI Stephen L. Seliger · 2006 to 2026
$28.9M
Healthy Aging Neighborhoods of Diversity Across LifespanZ01AG000513 · NIA · NATIONAL INSTITUTE ON AGING · PI EVANS, MICHELE K · 2001 to 2008
$6.8M
Carotid Revascularization and Medical Management for Asymptomatic CarotidStenosis Trial - Hemodynamics (CREST-H)R01NS097876 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI RONALD M LAZAR, DAVID SIGMUND LIEBESKIND · 2017 to 2026
$6.4M
ACL HHS 90AR5004ACL HHS 90AR5028CSRD VA I01 CX001621Intramural NIH HHS Z01 AG000513NIA NIH HHS P30 AG028747NINDS NIH HHS R01 NS097876NINDS NIH HHS U01 NS080168RRD VA I01 RX000995RRD VA IK2 RX003798
6 · The paper itself

Abstract

BackgroundOlder adults with mobility dysfunction are at risk for falls, hospitalization, and death. In an earlier pilot study, individuals with asymptomatic carotid artery stenosis (ACAS) demonstrated mobility dysfunction when compared to individuals without ACAS. We tested whether carotid stenosis affected mobility function in a larger community-dwelling cohort using the Invecchaire in Chianti (InCHIANTI) database.MethodsWe analyzed data from participants in the InCHIANTI study who completed a medical history, carotid duplex testing, and mobility function testing (Short Physical Performance Battery- SPPB). Participants with a history of stroke, transient ischemic attack, or carotid endarterectomy were excluded. 709 participants met inclusion criteria (116 ACAS, 593 no ACAS). Our analytic approach sought to evaluate the impact of stenosis on mobility after accounting for age, sex and cardiovascular risk factors. Age was stratified into 2 age-groups (65-74 and 75-84 years). Two-way ANOVA was used to test the effect of stenosis-group, age-group, and their interactions on SPPB score with sex as a covariate.ResultsStenosis-group (

Indexed as

Carotid StenosisMobility LimitationAgedAged, 80 and overAge FactorsAsymptomatic DiseasesDatabases, FactualDisability EvaluationFemaleFunctional StatusGeriatric AssessmentHumansIndependent LivingItalyMaleRisk Assessmentasymptomatic carotid stenosisbalancecarotid stenosismobility function

Identifiers

PMID40017230
PMCPMC12332504

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.