Evidence map›Paper›PMID 40017155›Full record

ArticleClinical and experimental otorhinolaryngology2025

Predominance of Auditory But Not Vestibular Deficits in a Mouse Model of Congenital Cytomegalovirus Infection.

Chi-Chieh Chang, Ying-Chang Lu, Po-Nien Tsao, Yen-Hui Chan, Yi-Shan Lee, Pei-Hsuan Lin, Cheng-Yu Hsieh, Wei-Chung Hsu, Chuan-Jen Hsu, Chun-Yi Lu and 1 more

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Article in Clinical and experimental otorhinolaryngology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Chi-Chieh ChangDepartment of Otolaryngology-Head and Neck Surgery, National Taiwan University Hospital, Taipei, Taiwan.
Ying-Chang LuDepartment of Otolaryngology-Head and Neck Surgery, National Taiwan University Hospital, Taipei, Taiwan.
Po-Nien TsaoDepartment of Pediatrics, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan.
Yen-Hui ChanDepartment of Otolaryngology-Head and Neck Surgery, National Taiwan University Hospital, Taipei, Taiwan.
Yi-Shan LeeDepartment of Otolaryngology-Head and Neck Surgery, National Taiwan University Hospital, Taipei, Taiwan.
Pei-Hsuan LinDepartment of Otolaryngology-Head and Neck Surgery, National Taiwan University Hospital, Taipei, Taiwan.
Cheng-Yu HsiehDepartment of Otolaryngology-Head and Neck Surgery, Taichung Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taichung, Taiwan.
Wei-Chung HsuDepartment of Otolaryngology-Head and Neck Surgery, National Taiwan University Hospital, Taipei, Taiwan.
Chuan-Jen HsuDepartment of Otolaryngology-Head and Neck Surgery, National Taiwan University Hospital, Taipei, Taiwan.
Chun-Yi LuDepartment of Pediatrics, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan.
Chen-Chi WuDepartment of Otolaryngology-Head and Neck Surgery, National Taiwan University Hospital, Taipei, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe aim of this study was to investigate the auditory and vestibular consequences of congenital cytomegalovirus (cCMV) infection in a C57BL/6 mouse model. This model, established via intraperitoneal inoculation, was designed to mimic clinical phenotypes.

methodsA cCMV infection model was developed by intraperitoneally inoculating C57BL/6 mice with murine cytomegalovirus. Auditory and vestibular functions were evaluated using auditory brainstem response tests, as well as open field, swim, and rotarod assessments. Histologic analysis of the inner ear was also conducted.

resultsThe study successfully established a cCMV infection model in C57BL/6 mice. Auditory deficits of varying severity and laterality were observed, mirroring the clinical spectrum seen in humans. In contrast, vestibular function was minimally affected and did not correlate with auditory deficits. Histopathologic examination revealed predominant damage to spiral ganglion neurons, while the vestibular organs remained relatively intact.

conclusionOur optimized mouse model effectively recapitulates the inner ear manifestations of human cCMV infection. The predominance of auditory over vestibular deficits provides valuable insights for developing targeted therapeutic interventions for cCMV-related inner ear sequelae.

Indexed as

C57BL MiceCongenital Cytomegalovirus InfectionIntraperitoneal InjectionSensorineural Hearing ImpairmentVestibular Diseases

Identifiers

PMID40017155
PMCPMC12400146

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.