Evidence map›Paper›PMID 40016834›Full record

ArticleBMC research notes2025

Candida albicans cell-free extract against human gastric cancer; an in-vitro study.

Babak Pakbin, Shaghayegh Pishkhan Dibazar, Samaneh Allahyari, Faezeh Mohammadi, Reza Ovissipour, Amir Peymani, Arian Amirvaresi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC research notes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Microbiota and cancer: Elucidating the role ofWorld journal of clinical oncology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Babak PakbinDepartment of Food Science and Technology, Texas A&M University, College Station, TX, 77843, USA.
Shaghayegh Pishkhan DibazarMedical Microbiology Research Center, Qazvin University of Medical Sciences, Qazvin, Iran.
Samaneh AllahyariMedical Microbiology Research Center, Qazvin University of Medical Sciences, Qazvin, Iran.
Faezeh MohammadiMedical Microbiology Research Center, Qazvin University of Medical Sciences, Qazvin, Iran. f.mohammadi@qums.ac.ir.
Reza OvissipourDepartment of Food Science and Technology, Texas A&M University, College Station, TX, 77843, USA. reza.ovissipour@ag.tamu.edu.
Amir PeymaniMedical Microbiology Research Center, Qazvin University of Medical Sciences, Qazvin, Iran.
Arian AmirvaresiDepartment of Food Science and Technology, Texas A&M University, College Station, TX, 77843, USA.

Funding

Qazvin University of Medical Sciences 400000387
6 · The paper itself

Abstract

objectiveYeast cell-free extracts and supernatants contain several compounds such as β-glucan, mannan, chitin, and mannoprotein with potent antitumor and other health-promoting activities. Candida albicans have been frequently and widely isolated from different habitats compared to other yeasts. The supernatant extracted from this yeast also contains β-glucan, chitin, and mannan compounds. This study investigates the anticancer, apoptosis-inducing, and downregulation of proinflammatory gene expression activities in normal and drug-resistant human stomach cancer cells (EPG and RDB cell lines) after 24 and 48 h treatment.

resultsWe found that Candida albicans supernatant-induced apoptosis suppressed the survivin gene expression in both cell lines and suppressed the expression of IL-8 and NF-ƙB genes in normal stomach cancer cells. IC

Indexed as

Antineoplastic AgentsCandida albicansStomach NeoplasmsApoptosisbeta-GlucansCell Line, TumorGene Expression Regulation, NeoplasticHumansInhibitor of Apoptosis ProteinsInterleukin-8NF-kappa BSurvivinAntineoplastic Agentsbeta-GlucansBIRC5 protein, humanInhibitor of Apoptosis ProteinsInterleukin-8NF-kappa BSurvivinAnticancer activityCandida albicansHuman stomach cancerYeast cell-free extract

Identifiers

PMID40016834
PMCPMC11869586

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.