ArticleBMC medicine2025
Accelerometer-measured physical activity, frailty, and all-cause mortality and life expectancy among middle-aged and older adults: a UK Biobank longitudinal study.
Article in BMC medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Article
- Wearable sensor-derived continuous physical activity dimensions and all-cause mortality in adults with diabetes and hypertension: insights from two population-based accelerometry cohorts.Acta diabetologica · 2026Article
- The joint association of sleep duration and physical activity with frailty among older adults: the first evidence from CHARLS.BMC geriatrics · 2026Article
- Machine learning derived abdominal aortic calcification is associated with physical frailty in community-dwelling adults: the UK Biobank Imaging Study.GeroScience · 2026Article
- Commentary on: Associations of accelerometer-measured light-intensity physical activity with mortality and incidence of cardiovascular disease and cancers: A prospective UK Biobank cohort analysis.Journal of sport and health science · 2026Article
- Association of physical activity and rest-activity rhythm with sustained attention and melatonin among community-dwelling older adults.European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity · 2026Article
- Physical Activity Monitoring in Adolescents and Young Adults With Cancer: Observational Feasibility Study.JMIR cancer · 2026Observational
- Article
- Frailty and Cardiometabolic Outcomes: A Narrative Review.Journal of clinical medicine · 2026Review
- Association between lifelong physical activity, physical fitness, and quality of life in older adults in Poland.Scientific reports · 2026Article
- Article
- Interaction between physical activity and deficit-based frailty on all-cause mortality in older adults: a prospective study of five population-based cohorts.The Lancet regional health. Western Pacific · 2026Article
- Relationship between 24-h movement behaviors and frailty-a scoping review.Frontiers in public health · 2026Article
- Associations of accelerometer-measured light-intensity physical activity with mortality and incidence of cardiovascular diseases and cancers: A prospective cohort study.Journal of sport and health science · 2025Article
- Exploring the Determinants and Correlates of Health-Enhancing Physical Activity of Adults in Eastern Poland.Sensors (Basel, Switzerland) · 2025Article
- Muscle Mass and Strength, Physical Function, and Health-Related Quality of Life After Roux-en-Y Gastric Bypass.Obesity surgery · 2025Article
- Joint Associations of Frailty and Cardiometabolic Diseases With Risk of All-Cause and Cardiac Mortality.JACC. Asia · 2025Article
- Future Designs of Clinical Trials in Nephrology: Integrating Methodological Innovation and Computational Power.Sensors (Basel, Switzerland) · 2025Review
- The Association Between Physical Activity and Frailty: China Health and Retirement Longitudinal Study (CHARLS).International journal of environmental research and public health · 2025Article
- Metabolic Status and Atrioventricular Block Risk: The Role of Physical Activity.Reviews in cardiovascular medicine · 2025Article
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Authors and funding
3 authors.
Funding
Abstract
backgroundPhysical activity (PA) is associated with reduced frailty and lower mortality rates among middle-aged and older adults. However, the extent to which total PA volume and specific PA intensities are associated with mortality risk across frailty status remains unclear. We aimed to investigate the interactive effects of accelerometer-measured PA with frailty on all-cause mortality and life expectancy.
methodsA total of 78,508 participants were sourced from the UK Biobank for analysis. Frailty index (FI) was used to assess frailty status. Physical activity and sedentary behavior were quantified through accelerometer measurements, capturing the total volume of physical activity (TVPA), moderate-to-vigorous-intensity physical activity (MVPA), light-intensity physical activity (LPA), and sedentary time (ST). Cox proportional hazard models were applied to calculate adjusted hazard ratios (HRs) and predict life expectancy.
resultsDuring a median follow-up of 6.9 years, 2618 deaths (2.9%) were identified. Compared with robust and physically active counterparts, individuals characterized by frailty, combined with the lowest levels of TVPA (HR 3.05, 95% CI: 2.50-3.71), MVPA (HR 2.65, 95% CI: 2.19-3.21), LPA (HR 2.26; 95% CI: 1.81-2.83), or the highest level of ST (HR 2.08, 95% CI: 1.66-2.61), were found to have the greatest risk of all-cause mortality after comprehensive adjustment. The dose-response relationship, assessed using restricted cubic splines, consistently demonstrated that regardless of frailty categories, higher levels of TVPA, MVPA, and LPA were associated with lower mortality risks, while higher ST level was associated with increased risk. Notably, across the frailty spectrum, individuals in the low tertile of TVPA, MVPA, and LPA, or the top tertile of ST, were associated with reduced life expectancy, with this pattern being more pronounced among frail men compared to frail women.
conclusionsOur findings highlighted the importance of increasing total PA volume, emphasizing MVPA and LPA, and reducing ST across the frailty spectrum to improve life expectancy.
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