Evidence map›Paper›PMID 40016733›Full record

ArticleBMC biology2025

Melanin deposition and key molecular features in Xenopus tropicalis oocytes.

Hongyang Yi, Weizheng Liang, Sumei Yang, Han Liu, Jiayu Deng, Shuhong Han, Xiaohui Feng, Wenjie Cheng, Yonglong Chen, Jing Hang and 2 more

Abstract read
In one paragraph

Article in BMC biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. VersatileProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Hongyang Yi *National Clinical Research Centre for Infectious Diseases, the Third People'S Hospital of Shenzhenand, the Second Affiliated Hospital of Southern University of Science and Technologyaq , Shenzhen, 518112, China.
Weizheng Liang *Hebei Provincial Key Laboratory of Systems Biology and Gene Regulation, Central Laboratory, The First Affiliated Hospital of Hebei North University, Zhangjiakou, Hebei, 075000, China.
Sumei Yang *National Clinical Research Centre for Infectious Diseases, the Third People'S Hospital of Shenzhenand, the Second Affiliated Hospital of Southern University of Science and Technologyaq , Shenzhen, 518112, China.
Han LiuNational Clinical Research Centre for Infectious Diseases, the Third People'S Hospital of Shenzhenand, the Second Affiliated Hospital of Southern University of Science and Technologyaq , Shenzhen, 518112, China.
Jiayu DengNational Clinical Research Centre for Infectious Diseases, the Third People'S Hospital of Shenzhenand, the Second Affiliated Hospital of Southern University of Science and Technologyaq , Shenzhen, 518112, China.
Shuhong HanNational Clinical Research Centre for Infectious Diseases, the Third People'S Hospital of Shenzhenand, the Second Affiliated Hospital of Southern University of Science and Technologyaq , Shenzhen, 518112, China.
Xiaohui FengDepartment of Obstetrics and Gynecology, The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, 519000, China.
Wenjie ChengDepartment of Urology, The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, 519000, China.
Yonglong ChenDepartment of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, 518055, China. chenyl@sustech.edu.cn.
Jing HangState Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China. hangjbysy@163.com.
Hongzhou LuNational Clinical Research Centre for Infectious Diseases, the Third People'S Hospital of Shenzhenand, the Second Affiliated Hospital of Southern University of Science and Technologyaq , Shenzhen, 518112, China. luhongzhou@fudan.edu.cn.
Rensen RanDepartment of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, 518055, China. sankeshumy@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMelanin pigmentation in oocytes is a critical feature for both the esthetic and developmental aspects of oocytes, influencing their polarity and overall development. Despite substantial knowledge of melanogenesis in melanocytes and retinal pigment epithelium cells, the molecular mechanisms underlying oocyte melanogenesis remain largely unknown.

resultsHere, we compare the oocytes of wild-type, tyr

conclusionsOverall, these findings suggest that further elucidation of Tyr-dependent and Mitf-independent mechanisms of melanin deposition at the animal pole will enhance our understanding of melanogenesis and Oogenesis.

Indexed as

MelaninsOocytesXenopusAnimalsFemaleMicrophthalmia-Associated Transcription FactorXenopus ProteinsMelaninsMicrophthalmia-Associated Transcription FactorXenopus ProteinsMelanogenesisMitochondrial cloudOogenesisXenopus tropicalis

Identifiers

PMID40016733
PMCPMC11866844

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.