ArticleBMC public health2025
Periodontitis and gastrointestinal cancer: a nationwide cohort study of NHANES 2009-2014.
Article in BMC public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Associations of oral health with colorectal cancer risk: accumulated evidences from observational studies.BMC cancer · 2026Pooled it
- Periodontitis-Associated Circulating EVs Promote Colorectal Cancer Progression via Carnosine-Mediated Acidosis Adaptation.Cell proliferation · 2026Article
- Association of red blood cell distribution width to albumin ratio with all-cause and cardiovascular mortality among adults with MASLD.BMC gastroenterology · 2026Article
- Periodontitis, colorectal cancer and associated factors: A cross-sectional study.Journal of clinical and experimental dentistry · 2026Review
- Periodontitis as a field of cancerization: association with carcinoembryonic antigen in colorectal cancer patients.Clinical oral investigations · 2025Article
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6 authors.
Funding
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Abstract
The association between periodontitis and gastrointestinal tract (GIT) cancer has undergone extensive investigation. However, there is ongoing controversy regarding the impact of periodontitis on the incidence and mortality rates among GIT cancer patients. This study aims to clarify the relationship between periodontitis and the risk as well as mortality rates of GIT cancer.
methodsThe data utilized in this study were obtained from the National Health and Nutrition Examination Survey (NHANES) database for the years 2009-2014, which included a total of 10,706 participants from the United States. The incidence and mortality rates of GIT cancer were analyzed in relation to periodontitis. To ensure the reliability of the results, additional adjustments for covariates and stratification analyses were conducted.
resultsIn the multivariate logistic regression analysis, various variables such as age, sex, race, BMI, income, education, smoking, alcohol consumption, hypertension, hyperlipidemia, and diabetes mellitus were adjusted for. The analysis revealed no positive association between periodontitis and an increased risk of total cancer or GIT cancer including colorectal cancer. However, periodontitis was found to be significantly associated with higher mortality rates among participants for all-cause (HR: 1.58; 95% CI: 1.26-2.00; P < 0.001), GIT cancer (HR: 1.65; 95% CI: 1.24-2.20; P < 0.001), and colorectal cancer (HR: 1.65; 95% CI: 1.24-2.19; P < 0.001) individually.
conclusionsThe study demonstrates that periodontitis is not associated with an increased risk of incidence for total cancer, or GIT cancer including colorectal cancer. However, it is significantly associated with a higher risk of mortality for all-cause, GIT cancer, and colorectal cancer among participants in the NHANES study.
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